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用于针对胰腺癌的双响应和双成像引导靶向协同光热化疗的透明质酸修饰及载有阿霉素的金纳米环

Hyaluronic Acid-Modified and Doxorubicin-Loaded Au Nanorings for Dual-Responsive and Dual-Imaging Guided Targeted Synergistic Photothermal Chemotherapy Against Pancreatic Carcinoma.

作者信息

Hu Lingyu, Song Zhengwei, Wu Bin, Yang Xiaodan, Chen Fei, Wang Xiaoguang

机构信息

Department of Surgery, The Second Affiliated Hospital of Jiaxing University, Jiaxing, 314000, People's Republic of China.

出版信息

Int J Nanomedicine. 2024 Dec 14;19:13429-13442. doi: 10.2147/IJN.S476936. eCollection 2024.

DOI:10.2147/IJN.S476936
PMID:39703980
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11656332/
Abstract

INTRODUCTION

Pancreatic carcinoma (PC) is a highly malignant digestive tumor. Nanotechnology-based minimally invasive techniques have been proposed to provide a new opportunity for PC treatment.

METHODS

A minimally invasive nanoplatform (named HA/DOX-AuNRs) is fabricated by HA modifying and DOX loading Au nanorings (AuNR). Because of their complicated geometric structure and tunable localized surface plasmon resonance peak in the second near-infrared laser window (NIR-II window), HA/DOX-AuNRs exhibit fluorescence/photoacoustic and photothermal properties, dual-responsive DOX release, and tumor-targeting ability. HA/DOX-AuNRs are expected to improve the tumor therapeutic efficiency and reduce undesirable side effects through fluorescence/photoacoustic dual-imaging guided targeted synergetic photothermal chemotherapy under NIR-II irradiation.

RESULTS

The morphological and physicochemical properties of HA/DOX-AuNRs are well-examined at first. The cytotoxicity, cellular uptake, and in vitro therapeutic effect of fluorescence/photoacoustic dual-imaging guided targeted synergetic photothermal chemotherapy are evaluated in Panc-1 cells. The in vivo biodistribution, anticancer effects, and systemic toxicity are investigated using PC xenograft models.

DISCUSSION

HA/DOX-AuNRs significantly improve the therapeutic efficacy in a dual-responsive and dual-imaging guided targeted synergy.

摘要

引言

胰腺癌（PC）是一种高度恶性的消化肿瘤。基于纳米技术的微创技术已被提出，为胰腺癌治疗提供了新的契机。

方法

通过用透明质酸（HA）修饰并负载阿霉素（DOX）制备金纳米环（AuNR），构建一种微创纳米平台（命名为HA/DOX-AuNRs）。由于其复杂的几何结构以及在第二近红外激光窗口（NIR-II窗口）中可调的局域表面等离子体共振峰，HA/DOX-AuNRs具有荧光/光声和光热特性、双响应性阿霉素释放以及肿瘤靶向能力。预计HA/DOX-AuNRs在近红外二区（NIR-II）照射下，通过荧光/光声双成像引导的靶向协同光热化疗，可提高肿瘤治疗效率并减少不良副作用。

结果

首先对HA/DOX-AuNRs的形态和理化性质进行了充分研究。在Panc-1细胞中评估了荧光/光声双成像引导的靶向协同光热化疗的细胞毒性、细胞摄取和体外治疗效果。使用胰腺癌异种移植模型研究了其体内生物分布、抗癌效果和全身毒性。

讨论

HA/DOX-AuNRs在双响应和双成像引导的靶向协同作用下显著提高了治疗效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26a0/11656332/f851919e2727/IJN-19-13429-g0008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26a0/11656332/7126cba8e58f/IJN-19-13429-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26a0/11656332/ca9cbb939eb3/IJN-19-13429-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26a0/11656332/85368e45d3f4/IJN-19-13429-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26a0/11656332/f851919e2727/IJN-19-13429-g0008.jpg

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