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本文引用的文献

1
Antibiotic Resistance Patterns Among Uropathogens in Female Outpatients Affected by Uncomplicated Cystitis: Focus on Fosfomycin Trometamol.女性单纯性膀胱炎门诊患者尿路病原体的抗生素耐药模式：重点关注磷霉素氨丁三醇。
Int J Antimicrob Agents. 2023 Nov;62(5):106974. doi: 10.1016/j.ijantimicag.2023.106974. Epub 2023 Sep 20.
2
Resistance to fosfomycin is increasing and is significantly associated with extended-spectrum β-lactamase-production in urinary isolates of Escherichia coli.大肠杆菌尿分离株中磷霉素耐药性增加，与超广谱β-内酰胺酶产生显著相关。
Med Microbiol Immunol. 2022 Dec;211(5-6):269-272. doi: 10.1007/s00430-022-00749-2. Epub 2022 Sep 3.
3
SUsceptibility and Resistance to Fosfomycin and other antimicrobial agents among pathogens causing lower urinary tract infections: findings of the SURF study.尿路致病性细菌对磷霉素及其他抗菌药物的耐药性和敏感性：SURF 研究结果。
Int J Antimicrob Agents. 2022 May;59(5):106574. doi: 10.1016/j.ijantimicag.2022.106574. Epub 2022 Mar 18.
4
Community-Acquired Urinary Tract Infection by in the Era of Antibiotic Resistance.社区获得性耐药淋病奈瑟菌尿路感染。
Biomed Res Int. 2018 Sep 26;2018:7656752. doi: 10.1155/2018/7656752. eCollection 2018.
5
Antimicrobial susceptibility and mechanisms of fosfomycin resistance in extended-spectrum β-lactamase-producing Escherichia coli strains from urinary tract infections in Wenzhou, China.中国温州尿路感染中产超广谱β-内酰胺酶大肠埃希菌的药敏情况及耐药机制研究
Int J Antimicrob Agents. 2017 Jul;50(1):29-34. doi: 10.1016/j.ijantimicag.2017.02.010. Epub 2017 Apr 26.
6
Susceptibility of contemporary isolates to fosfomycin: a systematic review of the literature.当代分离株对磷霉素的敏感性：文献系统评价。
Int J Antimicrob Agents. 2016 Apr;47(4):269-85. doi: 10.1016/j.ijantimicag.2016.02.001. Epub 2016 Feb 24.
7
Antimicrobial susceptibility of Escherichia coli from community-acquired urinary tract infections in Europe: the ECO·SENS study revisited.欧洲社区获得性尿路感染大肠埃希菌的药敏分析：ECO·SENS 研究再探讨。
Int J Antimicrob Agents. 2012 Jan;39(1):45-51. doi: 10.1016/j.ijantimicag.2011.09.013. Epub 2011 Nov 3.
8
International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases.国际临床实践指南：女性急性单纯性膀胱炎和肾盂肾炎的治疗（2010 年更新）：美国传染病学会和欧洲临床微生物学和传染病学会。
Clin Infect Dis. 2011 Mar 1;52(5):e103-20. doi: 10.1093/cid/ciq257.
9
Parallel increase in community use of fosfomycin and resistance to fosfomycin in extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli.社区中磷霉素使用的增加与产超广谱β-内酰胺酶（ESBL）大肠埃希菌对磷霉素耐药性的平行增加。
J Antimicrob Chemother. 2010 Nov;65(11):2459-63. doi: 10.1093/jac/dkq346. Epub 2010 Sep 16.
10
[Changes in the antimicrobial susceptibility of Escherichia coli isolates from community diagnosed urinary tract infections during the period 2003-2007. Multicentre study in Castilla la Mancha (Spain)].[2003年至2007年期间社区诊断的尿路感染患者分离出的大肠杆菌抗菌药敏性变化。西班牙卡斯蒂利亚-拉曼恰地区的多中心研究]
Rev Esp Quimioter. 2010 Mar;23(1):36-42.

医院外分离的大肠埃希菌尿液菌株对磷霉素仍保持敏感性。磷霉素耐药性与年龄及超广谱β-内酰胺酶（ESBL）产生密切相关。

Maintained susceptibility to fosfomycin in extra-hospitalary urinary isolates of Escherichia coli. Strong association of fosfomycin resistance with age and ESBL production.

作者信息

Hidalgo E, González-Torralba A, Ramón J, Alós J I

机构信息

Juan Ignacio Alós, Hospital Universitario de Getafe, Carr. Madrid - Toledo, Km 12,500, 28905 Getafe, Madrid, Spain.

出版信息

Rev Esp Quimioter. 2025 Feb;38(1):55-58. doi: 10.37201/req/016.2024. Epub 2024 Dec 20.

DOI:10.37201/req/016.2024
PMID:39704031
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11758869/
Abstract

OBJECTIVE

Escherichia coli is isolated in most of uncomplicated community-acquired urinary tract infections (UTI) and fosfomycin is one of the treatments of choice. We analyzed the evolution of fosfomycin resistance in extrahospitalary E. coli urinary isolates and whether age and extended spectrum beta-lactamase (ESBL) production were associated to antibiotic resistance.

METHODS

A retrospective descriptive study was conducted from January 2017 to December 2022 including E. coli isolates from extrahospitalary urine samples.

RESULTS

The susceptibility to fosfomycin remained above 95% during the study period. ESBL production and age above 80 years were significantly associated with increased fosfomycin resistance. We also analyzed the consumption of fosfomycin and it remained stable, although it was higher in the population >65 years.

CONCLUSIONS

Greater resistance is observed in ESBL-producing strains and in patients over 65 years of age. A stable consumption of fosfomycin is associated with low resistance percentages maintained over the time.

摘要

目的

在大多数非复杂性社区获得性尿路感染（UTI）中分离出大肠杆菌，磷霉素是首选治疗药物之一。我们分析了医院外大肠杆菌尿液分离株中磷霉素耐药性的演变情况，以及年龄和产超广谱β-内酰胺酶（ESBL）是否与抗生素耐药性相关。

方法

进行了一项回顾性描述性研究，时间跨度为2017年1月至2022年12月，纳入医院外尿液样本中的大肠杆菌分离株。

结果

在研究期间，对磷霉素的敏感性保持在95%以上。产ESBL和80岁以上年龄与磷霉素耐药性增加显著相关。我们还分析了磷霉素的消耗量，其保持稳定，尽管在65岁以上人群中消耗量更高。

结论

在产ESBL菌株和65岁以上患者中观察到更高的耐药性。磷霉素的稳定消耗量与长期维持的低耐药百分比相关。