医院外分离的大肠埃希菌尿液菌株对磷霉素仍保持敏感性。磷霉素耐药性与年龄及超广谱β-内酰胺酶（ESBL）产生密切相关。
Maintained susceptibility to fosfomycin in extra-hospitalary urinary isolates of Escherichia coli. Strong association of fosfomycin resistance with age and ESBL production.
作者信息
Hidalgo E, González-Torralba A, Ramón J, Alós J I
机构信息
Juan Ignacio Alós, Hospital Universitario de Getafe, Carr. Madrid - Toledo, Km 12,500, 28905 Getafe, Madrid, Spain.
出版信息
Rev Esp Quimioter. 2025 Feb;38(1):55-58. doi: 10.37201/req/016.2024. Epub 2024 Dec 20.
OBJECTIVE
Escherichia coli is isolated in most of uncomplicated community-acquired urinary tract infections (UTI) and fosfomycin is one of the treatments of choice. We analyzed the evolution of fosfomycin resistance in extrahospitalary E. coli urinary isolates and whether age and extended spectrum beta-lactamase (ESBL) production were associated to antibiotic resistance.
METHODS
A retrospective descriptive study was conducted from January 2017 to December 2022 including E. coli isolates from extrahospitalary urine samples.
RESULTS
The susceptibility to fosfomycin remained above 95% during the study period. ESBL production and age above 80 years were significantly associated with increased fosfomycin resistance. We also analyzed the consumption of fosfomycin and it remained stable, although it was higher in the population >65 years.
CONCLUSIONS
Greater resistance is observed in ESBL-producing strains and in patients over 65 years of age. A stable consumption of fosfomycin is associated with low resistance percentages maintained over the time.
目的
在大多数非复杂性社区获得性尿路感染（UTI）中分离出大肠杆菌，磷霉素是首选治疗药物之一。我们分析了医院外大肠杆菌尿液分离株中磷霉素耐药性的演变情况，以及年龄和产超广谱β-内酰胺酶（ESBL）是否与抗生素耐药性相关。
方法
进行了一项回顾性描述性研究，时间跨度为2017年1月至2022年12月，纳入医院外尿液样本中的大肠杆菌分离株。
结果
在研究期间，对磷霉素的敏感性保持在95%以上。产ESBL和80岁以上年龄与磷霉素耐药性增加显著相关。我们还分析了磷霉素的消耗量，其保持稳定，尽管在65岁以上人群中消耗量更高。
结论
在产ESBL菌株和65岁以上患者中观察到更高的耐药性。磷霉素的稳定消耗量与长期维持的低耐药百分比相关。
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