副交感神经功能障碍在GBA1相关帕金森病中普遍存在。
Parasympathetic Dysfunction Prevails in GBA1-Associated Parkinson's Disease.
作者信息
De Santis Tiziana, Cocco Antoniangela, Castiglioni Paolo, Ferrarin Maurizio, Mineri Rossana, Morenghi Emanuela, Avenali Micol, Albanese Alberto
机构信息
Department of Neurology, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
出版信息
Mov Disord Clin Pract. 2025 Mar;12(3):364-370. doi: 10.1002/mdc3.14314. Epub 2024 Dec 20.
BACKGROUND
The role played by sympathetic and parasympathetic autonomic branches in patients with Parkinson's disease carrying variants in the GBA1 gene (GBA-PD) is still elusive.
OBJECTIVES
To characterize cardiovascular autonomic function in GBA-PD and I-PD patients with early and mid-stage disease.
METHODS
These assessments were performed: cardiovascular autonomic tests, analysis of heart rate and blood pressure variability, cardiac noradrenergic imaging. The frequency and severity of autonomic symptoms were comparatively assessed with the SCOPA-AUT questionnaire.
RESULTS
Compared to the I-PD cohort, GBA-PD patients displayed an increased burden of autonomic symptoms. Autonomic tests revealed worse parasympathetic scores in GBA-PD while sympathetic indexes and the degree of cardiac sympathetic binding were comparable in the two groups. Heart rate variability indexes also revealed lower vagal modulation in the GBA-PD group.
CONCLUSIONS
The cardiovascular autonomic profile in GBA PD is characterized by a prominent cardiovagal dysfunction compared to I-PD.
背景
在携带GBA1基因变异的帕金森病患者（GBA-PD）中，交感神经和副交感神经自主分支所起的作用仍不明确。
目的
对早期和中期疾病的GBA-PD和特发性帕金森病（I-PD）患者的心血管自主神经功能进行特征描述。
方法
进行了以下评估：心血管自主神经测试、心率和血压变异性分析、心脏去甲肾上腺素能成像。使用SCOPA-AUT问卷对自主神经症状的频率和严重程度进行比较评估。
结果
与I-PD队列相比，GBA-PD患者的自主神经症状负担增加。自主神经测试显示GBA-PD患者的副交感神经评分更差，而两组的交感神经指标和心脏交感神经结合程度相当。心率变异性指标也显示GBA-PD组的迷走神经调节较低。
结论
与I-PD相比，GBA-PD的心血管自主神经特征表现为明显的心脏迷走神经功能障碍。
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