Shure D, Moser K M, Konopka R
Am Rev Respir Dis. 1985 Feb;131(2):290-1. doi: 10.1164/arrd.1985.131.2.290.
We evaluated the risk, sensitivity, and specificity of transbronchial needle aspiration (TBNA) in a canine model of unilateral Streptococcus pneumoniae pneumonia and compared the results with our previous studies of these parameters in transthoracic needle aspiration (TTN), a catheter-brush (CB), and transbronchial biopsy (TBB) in the same model. The TBNA was performed in 10 dogs with right lower lobe S. pneumoniae pneumonia. The procedure was uncomplicated, but both the sensitivity and specificity were low (3 of 10 cultures yielded S. pneumoniae; only 1 of the 3 was a pure culture). This compares unfavorably with our experience with the other procedures: 9 of 10 cultures were pure with TBB and CB, and the remaining culture was sterile; 10 of 10 were pure with TTN. Given the present unprotected form of the bronchoscopic aspirating needle, TBNA does not appear to be useful in the diagnosis of bacterial pneumonia despite its usefulness in the diagnosis of intrathoracic malignancy.
我们在单侧肺炎链球菌肺炎的犬模型中评估了经支气管针吸活检（TBNA）的风险、敏感性和特异性，并将结果与我们之前在同一模型中对经胸针吸活检（TTN）、导管刷检（CB）和经支气管活检（TBB）的这些参数的研究进行了比较。对10只患有右下叶肺炎链球菌肺炎的犬进行了TBNA。该操作没有并发症，但敏感性和特异性都很低（10次培养中有3次培养出肺炎链球菌；3次中只有1次是纯培养）。这与我们在其他操作中的经验相比并不理想：TBB和CB的10次培养中有9次是纯培养，其余1次培养无菌；TTN的10次培养都是纯培养。鉴于目前支气管镜吸针无保护的形式，尽管TBNA在诊断胸内恶性肿瘤方面有用，但在细菌性肺炎的诊断中似乎并无用处。
