免疫检查点抑制剂诱导的原发性肾上腺皮质功能减退：一例报告
Immune Checkpoint Inhibitor-Induced Primary Adrenal Insufficiency: A Case Report.
作者信息
Gupta Rahul, Lubkin Cary
机构信息
Cooper University Hospital, Department of Emergency Medicine, Camden, New Jersey.
出版信息
Clin Pract Cases Emerg Med. 2024 Nov;8(4):339-342. doi: 10.5811/cpcem.20448.
Abstract
INTRODUCTION
One of the less common and more life-threatening etiologies of adrenal insufficiency is immune checkpoint inhibitor (ICI)-induced primary adrenal insufficiency (PAI). Patients typically present with fatigue, malaise, and nausea and are treated empirically with hydrocortisone.
CASE REPORT
We present the case of a 59-year-old female who presented with hypotension, which initially was thought to be due to hypovolemia or medication-related, but was ultimately found to have PAI.
CONCLUSION
This case highlights the importance of early detection of ICI-induced primary adrenal insufficiency, given its associated morbidity and mortality and its incidence in patients with a history of immunotherapy.
摘要
引言
肾上腺功能不全较少见且更具生命威胁性的病因之一是免疫检查点抑制剂（ICI）诱导的原发性肾上腺功能不全（PAI）。患者通常表现为疲劳、不适和恶心，并接受氢化可的松经验性治疗。
病例报告
我们报告一例59岁女性患者，该患者出现低血压，最初认为是由于血容量不足或药物相关，但最终发现患有PAI。
结论
鉴于ICI诱导的原发性肾上腺功能不全的相关发病率、死亡率及其在有免疫治疗史患者中的发生率，本病例强调了早期检测的重要性。
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Semin Oncol. 2023 Dec;50(6):144-148. doi: 10.1053/j.seminoncol.2023.11.003. Epub 2023 Dec 6.
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