伴有肌酸磷酸激酶升高的结节病性肌病

Sarcoid myopathy with elevated creatine phosphokinase.

作者信息

Ando D G, Lynch J P, Fantone J C

出版信息

Am Rev Respir Dis. 1985 Feb;131(2):298-300. doi: 10.1164/arrd.1985.131.2.298.

DOI:10.1164/arrd.1985.131.2.298

Abstract

Acute inflammatory myopathy complicating sarcoidosis is rare, and its prognosis and appropriate therapy have not been defined well. We describe a patient with chronic sarcoidosis who, during a 3-month period, developed an acute proximal myopathy associated with marked elevations in creatine phosphokinase (CPK) and extensive granulomatous inflammation on muscle biopsy. High-dose corticosteroids were dramatically effective in inducing remission, with resolution of all signs and symptoms of the myopathy and normalization of CPK.

摘要

结节病并发急性炎症性肌病较为罕见，其预后及恰当治疗方法尚未明确界定。我们描述了一名患有慢性结节病的患者，在3个月期间，出现急性近端肌病，肌酸磷酸激酶（CPK）显著升高，肌肉活检显示广泛的肉芽肿性炎症。大剂量皮质类固醇在诱导缓解方面效果显著，肌病的所有体征和症状均消失，CPK恢复正常。