Qi Guijie, Yao Ling, Liu Zhiming, Guo Wanru, Liu Heng, Zhang Jinghua, He Yulian, Jiang Tiancong
Department of Genetics, Tangshan Maternal and Children Health Hospital, Tangshan City, Hebei, China.
Department of Clinical Laboratory, The Hospital of Maternal and Health of Tangshan, Tangshan City, Hebei, China.
J Perinat Med. 2024 Dec 23;53(2):149-157. doi: 10.1515/jpm-2024-0184. Print 2025 Feb 25.
Placental growth factor (PlGF) has been reported as a good biomaker for the prediction of preeclampsia occurring in the short term in singleton pregnancies, in women presenting with clinical suspicion of preeclampsia. This study aims to evaluate the predictive value of the PlGF in twin pregnancies.
Twin pregnancies with clinically suspected preeclampsia (24 weeks 0 days-36 weeks 6 days of gestation) were enrolled in this study. The threshold of PlGF for predicting preeclampsia was determined on the basis of a receiver-operating characteristic curve to predict preeclampsia and the short-term occurrence of preeclampsia.
Within 1 week, 2 weeks, and 4 weeks of testing respectively, a cutoff value of 215 pg/mL for PlGF to predict preeclamsia in twin pregnancies suspected to have preeclampsia has a specificity of 100 %[51.7 %, 100 %], 100 %[62.9 %, 100 %], 93.8 %[667.6 %, 99.7 %], and a negative predictive value of 100 %[94.8 %, 100 %], 100 %[95.0 %, 100 %], and 98.9 %[93.0 %, 99.9 %].
A cutoff value of 215 pg/mL for PlGF is a useful tool to exclude the development of preeclampsia within 4 weeks of measurement.
胎盘生长因子（PlGF）已被报道为预测单胎妊娠短期内发生先兆子痫的良好生物标志物，适用于临床怀疑为先兆子痫的女性。本研究旨在评估PlGF在双胎妊娠中的预测价值。
本研究纳入临床怀疑为先兆子痫的双胎妊娠（妊娠24周0天至36周6天）。基于预测先兆子痫和短期内先兆子痫发生情况的受试者工作特征曲线，确定预测先兆子痫的PlGF阈值。
分别在检测后1周、2周和4周内，对于疑似先兆子痫的双胎妊娠，PlGF预测先兆子痫的临界值为215 pg/mL时，特异性分别为100%[51.7%，100%]、100%[62.9%，100%]、93.8%[667.6%，99.7%]，阴性预测值分别为100%[94.8%，100%]、100%[95.0%，100%]、98.9%[93.0%，99.9%]。
PlGF临界值为215 pg/mL是排除测量后4周内发生先兆子痫的有用工具。
