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在前列腺癌骨转移患者中AMPK下调Beclin-1：一项观察性研究。

AMPK down-regulating Beclin-1 in prostate cancer patients with bone metastasis: An observational study.

作者信息

Chen Jiaxing, Hu Lingyun, Zhou Wangguang, Wang Chaoyang, Zhou Xuewu

机构信息

Department of Urology, The People's Hospital of Jiangshan, Quzhou , Zhejiang Province, China.

出版信息

Medicine (Baltimore). 2024 Dec 20;103(51):e41024. doi: 10.1097/MD.0000000000041024.

DOI:10.1097/MD.0000000000041024
PMID:39705435
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11666198/
Abstract

Bone metastasis is frequently seen in patients, particularly those with prostate cancer, showing a higher hazard that deteriorates the quality of life of patients, leading to poor prognosis, which eventually causes significant mortality in prostate cancer patients. The present study investigated the mechanism of prostate cancer with bone metastasis by utilizing prostate specimens from patients. A total of 418 patients were initially enrolled for clinical analysis, including age, prostate-specific antigen (PSA) levels, body mass index (BMI), prostate magnetic resonance imaging (MRI), and bone MRI, while pathological analysis included grade group and carcinoma of the prostate. Patients were divided into a prostate cancer with bone metastasis group (group 1, prostate cancer patients) and benign prostate patient group (group 2, control group) and underwent subsequent immunohistochemical (IHC) detection. Expression of AMPK/Beclin-1 signaling pathways was analyzed through immunohistochemistry. Finally, 46 patients with prostate cancer bone metastasis (prostate cancer patients) and 61 patients with benign prostate (control group) met the inclusion criteria. We examined the expression levels of Beclin-1 and AMPK in human prostate tissues by IHC and found that Beclin-1 levels were negatively correlated with AMPK in prostate cancer with bone metastasis (P < .05). The results of this study suggest that AMPK-Beclin-1 significantly reduces prostate cancer metastasis to the bone in human tissues.

摘要

骨转移在患者中很常见，尤其是前列腺癌患者，其具有较高的风险，会恶化患者的生活质量，导致预后不良，最终导致前列腺癌患者的死亡率显著升高。本研究通过利用患者的前列腺标本，探究了前列腺癌骨转移的机制。最初共纳入418例患者进行临床分析，包括年龄、前列腺特异性抗原（PSA）水平、体重指数（BMI）、前列腺磁共振成像（MRI）和骨MRI，而病理分析包括分级组和前列腺癌。患者被分为前列腺癌骨转移组（第1组，前列腺癌患者）和良性前列腺患者组（第2组，对照组），并随后进行免疫组织化学（IHC）检测。通过免疫组织化学分析AMPK/Beclin-1信号通路的表达。最后，46例前列腺癌骨转移患者（前列腺癌患者）和61例良性前列腺患者（对照组）符合纳入标准。我们通过IHC检测了人前列腺组织中Beclin-1和AMPK的表达水平，发现骨转移前列腺癌中Beclin-1水平与AMPK呈负相关（P < 0.05）。本研究结果表明，AMPK-Beclin-1可显著降低人组织中前列腺癌向骨的转移。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/820f/11666198/609df27d5144/medi-103-e41024-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/820f/11666198/831d4f82bec6/medi-103-e41024-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/820f/11666198/7b73bf33764e/medi-103-e41024-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/820f/11666198/04c44518e1c0/medi-103-e41024-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/820f/11666198/acb9c5cc912b/medi-103-e41024-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/820f/11666198/c9d654bc76ba/medi-103-e41024-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/820f/11666198/609df27d5144/medi-103-e41024-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/820f/11666198/831d4f82bec6/medi-103-e41024-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/820f/11666198/7b73bf33764e/medi-103-e41024-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/820f/11666198/04c44518e1c0/medi-103-e41024-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/820f/11666198/acb9c5cc912b/medi-103-e41024-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/820f/11666198/c9d654bc76ba/medi-103-e41024-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/820f/11666198/609df27d5144/medi-103-e41024-g006.jpg

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