重新评估唾液用于监测茶碱浓度的情况。
Re-evaluation of saliva for monitoring theophylline concentrations.
作者信息
Rylance G W, Beswick D T, Cullen R E, Roberts D G
出版信息
Arch Dis Child. 1985 Jan;60(1):66-8. doi: 10.1136/adc.60.1.66.
Abstract
Variability of the mixed saliva/plasma theophylline relation was examined in seven children aged 2 to 13 years. Good correlation between plasma and saliva concentrations was found, but on the three occasions there was considerable inter- and intrapatient variability. There was no significant or consistent relation between unstimulated and stimulated saliva concentrations or between saliva concentrations and sample volumes. Plasma theophylline concentrations cannot be predicted accurately from saliva values.
摘要
对7名年龄在2至13岁的儿童的混合唾液/血浆中茶碱的关系变异性进行了研究。发现血浆和唾液浓度之间存在良好的相关性，但在三次检测中，患者间和患者内均存在相当大的变异性。未刺激和刺激后的唾液浓度之间、唾液浓度与样本体积之间均无显著或一致的关系。无法根据唾液值准确预测血浆茶碱浓度。
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本文引用的文献
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Saliva theophylline concentrations after a single oral dose.单次口服剂量后的唾液茶碱浓度。
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Reproducibility of saliva and plasma theophylline levels following single dose administration of two sustained release preparations.单次服用两种缓释制剂后唾液和血浆中茶碱水平的重现性。
Br J Clin Pharmacol. 1983 Apr;15(4):407-10. doi: 10.1111/j.1365-2125.1983.tb01522.x.
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Do saliva concentrations predict plasma unbound theophylline concentrations? A problem re-examined.唾液浓度能否预测血浆中游离茶碱的浓度？重新审视的一个问题。
Br J Clin Pharmacol. 1984 Jan;17(1):9-14. doi: 10.1111/j.1365-2125.1984.tb04991.x.
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Evaluation of oral bronchodilator therapy in asthmatic children. Bronchodilators in asthmatic children.哮喘儿童口服支气管扩张剂治疗的评估。哮喘儿童使用的支气管扩张剂。
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