Lin Sung-Yao, Schmidt Edward N, Takahashi-Yamashiro Kei, Macauley Matthew S
Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada.
Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada.
Semin Immunol. 2025 Mar;77:101925. doi: 10.1016/j.smim.2024.101925. Epub 2024 Dec 19.
Cell surface complex carbohydrates, known as glycans, are positioned to be the first point of contact between two cells. Indeed, interactions between glycans with glycan-binding can modulate cell-cell interactions. This concept is particularly relevant for immune cells, which use an array of glycan-binding proteins to help in the process of differentiating 'self' from 'non-self'. This is exemplified by the sialic acid-binding immunoglobulin-type lectins (Siglecs), which recognize sialic acid. Given that sialic acid is relatively unique to vertebrates, immune cells leverage Siglecs to recognize sialic acid as a marker of 'self'. Siglecs serve many biological roles, with most of these functions regulated through interactions with their sialoglycan ligands. In this review, we provide a comprehensive update on the ligands of Siglecs and how Siglec-sialoglycan interactions help regulate immune cells in the adaptive and innate immune system.
细胞表面的复合碳水化合物，即聚糖，处于两个细胞之间的首个接触点位置。实际上，聚糖与聚糖结合蛋白之间的相互作用能够调节细胞间相互作用。这一概念对于免疫细胞尤为重要，免疫细胞利用一系列聚糖结合蛋白来协助区分“自身”与“非自身”。唾液酸结合免疫球蛋白样凝集素（Siglecs）识别唾液酸便是一个例证。鉴于唾液酸在脊椎动物中相对独特，免疫细胞利用Siglecs将唾液酸识别为“自身”的标志物。Siglecs具有多种生物学功能，其中大多数功能通过与唾液酸糖配体的相互作用来调节。在本综述中，我们全面更新了Siglecs的配体以及Siglec-唾液酸糖相互作用如何在适应性和先天性免疫系统中帮助调节免疫细胞的相关内容。
