Villa Andrés M, Manin Analisa, Seimandi Carla, Guerrero Diego Alarcón, Ramos Graciela
División Neurología. Hospital Gral. de Agudos Dr. José María Ramos Mejía, Bs. As, Argentina; Centro Argentino de Neuroinmunología (CADENI). Facultad de Medicina, Universidad de Buenos Aires. Argentina.
División Neurología. Hospital Gral. de Agudos Dr. José María Ramos Mejía, Bs. As, Argentina; Centro Argentino de Neuroinmunología (CADENI). Facultad de Medicina, Universidad de Buenos Aires. Argentina.
Mult Scler Relat Disord. 2025 Jan;93:106223. doi: 10.1016/j.msard.2024.106223. Epub 2024 Dec 12.
Distinct clinical course patterns have been identified between AQP4-IgG-positive and AQP4-IgG-negative NMOSD patients.
This study aimed to evaluate the differences between AQP4-IgG-seropositive and AQP4-IgG-seronegative NMOSD patients in a single centre in Argentina.
We performed a retrospective cross-sectional study of 108 NMOSD patients in the city of Buenos Aires, Argentina.
We selected 94 for analysis. 77 patients (82 %) were AQP4-IgG positive. In the AQP4-IgG positive group, the ratio of male to female was 1:10 vs. 1:1.2 in the seronegative group (p = 0.001). Relapses were observed in 76 out of 77 (99 %) AQP4-IgG positive patients versus 3 out of 17 (17.6 %) AQP4-IgG negative patients (p = 0.01). In the seropositive group, other autoimmune diseases were present in 34/77 patients (44 %) vs. 2/12 (12 %) in the seronegative patients, a statistically significant difference (p = 0.009). 81 % of the seropositive group had an early adulthood onset (EAO-NMOSD) compared to 35 % in the seronegative group. All AQP4+ patients positive received treatment with monoclonal antibodies. In AQP4-IgG- NMOSD patients the use of immunosuppressive treatment was more common.
Female predominance, EAO-NMOSD, recurrence course and a high prevalence of autoimmune disease in AQP4-IgG-positive patients demonstrated a more pronounced autoimmunity profile.
已确定水通道蛋白4免疫球蛋白G（AQP4-IgG）阳性和AQP4-IgG阴性视神经脊髓炎谱系障碍（NMOSD）患者具有不同的临床病程模式。
本研究旨在评估阿根廷单一中心中AQP4-IgG血清阳性和AQP4-IgG血清阴性NMOSD患者之间的差异。
我们对阿根廷布宜诺斯艾利斯市的108例NMOSD患者进行了一项回顾性横断面研究。
我们选取了94例进行分析。77例患者（82%）为AQP4-IgG阳性。在AQP4-IgG阳性组中，男女比例为1:10，而血清阴性组为1:1.2（p = 0.001）。77例AQP4-IgG阳性患者中有76例（99%）出现复发，而17例AQP4-IgG阴性患者中有3例（17.6%）出现复发（p = 0.01）。在血清阳性组中，34/77例患者（44%）存在其他自身免疫性疾病，而血清阴性患者中为2/12例（12%），差异具有统计学意义（p = 0.009）。血清阳性组中81%的患者在成年早期发病（早发型NMOSD），而血清阴性组为35%。所有AQP4+阳性患者均接受单克隆抗体治疗。在AQP4-IgG-NMOSD患者中，免疫抑制治疗的使用更为常见。
AQP4-IgG阳性患者中女性占主导、早发型NMOSD、复发病程以及自身免疫性疾病的高患病率显示出更明显的自身免疫特征。
