Reda Rasha M, Zaki Eman M, Aioub Ahmed A A, Metwally Mohamed M M, Mahsoub Fatma
Department of Aquatic Animal Medicine, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Sharkia 44511, Egypt.
Department of Reproduction and Fish Physiology, Central laboratory for Aquaculture Research (CLAR), Abbassa, Agriculture research Centre, Giza 44662, Egypt.
Aquat Toxicol. 2025 Feb;279:107213. doi: 10.1016/j.aquatox.2024.107213. Epub 2024 Dec 15.
This study aims to examine the restorative impact of corn cob biochar (CCB) on pendimethalin (PMD)-induced toxicity in Oreochromis niloticus. Fish were divided into four groups: the first control group without treatment, the second group (CCB) exposed to 10 g CCB/L, the third group (PDM) exposed to 0.355 mg PDM/L, and the fourth group (PDM+ CCB) receiving both 0.355 mg PDM/L and 10 g CCB/L for 30 days. PDM exposure resulted in behavioral alterations, low survival rate (73.33 %), hematological and biochemical impairments, increased oxidative stress, suppressed immunity, and histopathological damage in gill, liver, and brain tissues. Co-treatment with CCB significantly alleviated these effects, as evidenced by improved survival rate (88.88 %), hematological, biochemical, and antioxidant-immune parameters and reduced histopathological alterations. In conclusion, CCB demonstrated a promising potential to mitigate PDM-induced toxicity in O. niloticus by enhancing physiological, biochemical, and histological resilience.
本研究旨在探讨玉米芯生物炭（CCB）对二甲戊灵（PMD）诱导的尼罗罗非鱼毒性的修复作用。将鱼分为四组：第一组为未处理的对照组，第二组（CCB组）暴露于10 g CCB/L，第三组（PDM组）暴露于0.355 mg PDM/L，第四组（PDM + CCB组）同时接受0.355 mg PDM/L和10 g CCB/L处理30天。暴露于PMD导致行为改变、低存活率（73.33%）、血液学和生化指标受损、氧化应激增加、免疫力抑制以及鳃、肝脏和脑组织的组织病理学损伤。与CCB联合处理显著减轻了这些影响，表现为存活率提高（88.88%）、血液学、生化和抗氧化免疫参数改善以及组织病理学改变减少。总之，CCB通过增强生理、生化和组织学弹性，显示出减轻PMD诱导的尼罗罗非鱼毒性的潜在前景。
