Stone Spenser H, Rathmell Jeffrey C, Bader Jackie E
Department of Pathology Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Department of Pathology Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Cell Chem Biol. 2024 Dec 19;31(12):2021-2023. doi: 10.1016/j.chembiol.2024.11.008.
Obesity is a leading risk factor and a negative prognostic indicator for many cancers. In a recent issue of Science Immunology, Bagchi et al. identified that tumor-associated macrophages upregulate GPR65 in response to obesity-driven intratumor acidity resulting in reduced effector function to promote tumor growth..
肥胖是许多癌症的主要风险因素和不良预后指标。在最近一期的《科学免疫学》杂志上，巴格奇等人发现，肿瘤相关巨噬细胞会因肥胖驱动的肿瘤内酸度而上调GPR65，从而导致效应功能降低，促进肿瘤生长。
