Miranda Ian, Jahan Nusrat, Shevde Lalita A
Medical Scientist Training Program, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Division of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL, USA.
Cell Rep Med. 2025 Jan 21;6(1):101872. doi: 10.1016/j.xcrm.2024.101872. Epub 2024 Dec 19.
Metastasis is a main cause of cancer-related death, and a deeper understanding of the metastatic process will inform more targeted and mechanistic approaches that can abrogate challenges in treatment efficacy and toxicity. Several steps throughout the metastatic cascade, from angiogenesis to secondary tumor formation, offer specific vulnerabilities to therapies that can lead to the decline or cessation of metastatic progression. A deeper understanding of the metastatic cascade also allows combination systemic therapies to be used synergistically. In this review, we describe current treatment modalities in the context of multiple steps of the metastatic cascade. We highlight their mechanisms and present their efficacy across multiple cancers. This work also presents targets within the metastatic cascade in need of more research that can advance the landscape of treatments and lead to the goal of metastatic cancer remission.
转移是癌症相关死亡的主要原因，更深入地了解转移过程将为更具针对性和机制性的方法提供依据，这些方法可以消除治疗效果和毒性方面的挑战。从血管生成到继发性肿瘤形成的整个转移级联过程中的几个步骤，为可能导致转移进展下降或停止的治疗提供了特定的靶点。对转移级联的更深入理解也允许联合全身治疗协同使用。在这篇综述中，我们在转移级联的多个步骤的背景下描述了当前的治疗方式。我们强调了它们的机制，并展示了它们在多种癌症中的疗效。这项工作还提出了转移级联中需要更多研究的靶点，这些研究可以推动治疗领域的发展，并实现转移性癌症缓解的目标。
