Feng Yiwei, Rao Zhijian, Tian Xu, Hu Yi, Yue Liantian, Meng Yifan, Zhong Qiuling, Chen Wei, Xu Wenlong, Li Haoran, Hu Yingjia, Shi Rengfei
School of Exercise and Health, Shanghai University of Sport, Shanghai, 200438, China.
School of Physical Education, Shanghai Normal University, Shanghai, 200234, China.
Free Radic Biol Med. 2025 Feb 1;227:619-628. doi: 10.1016/j.freeradbiomed.2024.12.038. Epub 2024 Dec 18.
The mitochondrial open reading frame of 12S rRNA-c (MOTS-c) is a biologically active mitochondria-derived peptide. However, the relationship between MOTS-c, skeletal muscle mitochondrial function, and endurance exercise adaptations is unknown. Here, we tested indices such as maximal oxygen uptake and serum MOTS-c levels in marathon runners and sedentary subjects. In addition, we tested aerobic exercise capacity, skeletal muscle mitochondrial respiration rate, and serum MOTS-c levels in mice subjected to long-term endurance training groups and sedentary groups. Our results indicated a close association between serum MOTS-c levels and aerobic exercise capacity. Circulating MOTS-c levels are expected to be an important indicator for predicting aerobic exercise capacity and assessing body fat status, endurance training load, and physical function. More importantly, we found that endurance training may enhance the mitochondrial respiratory function of skeletal muscle by promoting the secretion of MOTS-c and activating the AMPK/PGC-1α pathway.
线粒体12S rRNA-c开放阅读框（MOTS-c）是一种具有生物活性的线粒体衍生肽。然而，MOTS-c、骨骼肌线粒体功能和耐力运动适应性之间的关系尚不清楚。在此，我们检测了马拉松运动员和久坐不动者的最大摄氧量和血清MOTS-c水平等指标。此外，我们还检测了长期耐力训练组和久坐组小鼠的有氧运动能力、骨骼肌线粒体呼吸速率和血清MOTS-c水平。我们的结果表明血清MOTS-c水平与有氧运动能力密切相关。循环MOTS-c水平有望成为预测有氧运动能力以及评估体脂状况、耐力训练负荷和身体功能的重要指标。更重要的是，我们发现耐力训练可能通过促进MOTS-c的分泌和激活AMPK/PGC-1α通路来增强骨骼肌的线粒体呼吸功能。
