外科手术与麻醉领域平台试验的全球合作。

Global collaboration between platform trials in surgery and anaesthesia.

作者信息

Glasbey James, Webb Steve A, Peel Trisha, Pinkney Thomas D, Myles Paul S

机构信息

Academic Department of Surgery, University of Birmingham, Birmingham, UK.

Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; St John of God Healthcare, Melbourne, VIC, Australia.

出版信息

Br J Anaesth. 2025 Feb;134(2):259-262. doi: 10.1016/j.bja.2024.09.021. Epub 2024 Dec 20.

DOI:10.1016/j.bja.2024.09.021

PMID:39706702

Abstract

Large, randomised trials are the bedrock of evidence-based medicine, but the resources required to complete such trials greatly limit the number of important clinical questions that can be addressed within a reasonable period of time. Adaptive platform trials can identify effective, ineffective, or harmful treatments faster. These trials have been shown to deliver rapid evidence through the COVID-19 pandemic and are now being adopted across surgery and anaesthesia, with many opportunities for surgeons, anaesthetists, and other perioperative physicians to conduct and collaborate in platform trials.

摘要

大型随机试验是循证医学的基石，但完成此类试验所需的资源极大地限制了在合理时间内能够解决的重要临床问题的数量。适应性平台试验能够更快地识别有效、无效或有害的治疗方法。这些试验已被证明在新冠疫情期间能够迅速提供证据，目前正在外科手术和麻醉领域广泛应用，外科医生、麻醉医生和其他围手术期医生有很多机会参与平台试验并开展合作。