细菌基因内倒位：多样性的新层次。

Bacterial intragenic inversions: a new layer of diversity.

作者信息

Hall Brantley, Jiang Xiaofang

机构信息

Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, College Park, MD, USA; Center for Bioinformatics and Computational Biology, University of Maryland, College Park, College Park, MD, USA.

National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.

出版信息

Trends Genet. 2025 Mar;41(3):183-184. doi: 10.1016/j.tig.2024.12.002. Epub 2024 Dec 19.

DOI:10.1016/j.tig.2024.12.002

PMID:39706706

Abstract

DNA inversions in bacteria were known to create diversity through intergenic or partial intergenic changes. Now, Chanin, West, et al. reveal intragenic inversions, enabling single genes to encode multiple protein variants via sequence recoding or truncation - an unexpected mechanism for expanding protein diversity without increasing genome size.

摘要

已知细菌中的DNA倒位通过基因间或部分基因间的变化产生多样性。现在，查宁、韦斯特等人揭示了基因内倒位，使单个基因能够通过序列重新编码或截短来编码多种蛋白质变体——这是一种在不增加基因组大小的情况下扩展蛋白质多样性的意外机制。