Abeid Mohamed, Zaitoun Nahla
Cairo University, Giza, Egypt.
Zagazig University, Zagazig, Egypt.
Obes Surg. 2025 Jan;35(1):280-284. doi: 10.1007/s11695-024-07609-3. Epub 2024 Dec 20.
We previously reported the utility of endoscopic band ligation (EBL) in weight loss in a female patient with obesity. This study aimed to evaluate the safety of weight loss using EBL in a larger cohort.
This prospective cohort study included 13 female patients aged ≥ 18 years with a body mass index of ≥ 30 kg/m who were unwilling to undergo bariatric surgery. Patients with obesity-related comorbidities such as diabetes, hypertension, dyslipidemia, and cardiovascular disease were included. Patients with a history of bariatric surgery and those with clinical manifestations of gastroparesis, portal hypertension, liver cirrhosis, and coagulopathies were excluded. Primary study outcomes were technical feasibility and safety, and secondary study outcomes were the percentage of total weight loss, excess weight loss, and the change in gastroparesis clinical symptom index at 1 month after surgery.
No serious complications occurred during the endoscopy or immediately after that. All patients experienced epigastric pain, nausea, and vomiting for the first 3 days, with one patient developing mild hematemesis on the second day that stopped spontaneously and revealed no abnormalities on endoscopy. At 1 month after EBL, the mean percent excess weight loss and total weight loss were 22.3% ± 9.9% and 7.8% ± 2.5%, respectively.
EBL is an effective and safe intervention for obesity management. Further studies with larger cohorts are warranted to comprehensively evaluate of the long-term efficacy and safety of EBL for obesity management.
我们之前报道了内镜下套扎术（EBL）在一名肥胖女性患者体重减轻方面的效用。本研究旨在评估在更大队列中使用EBL减肥的安全性。
这项前瞻性队列研究纳入了13名年龄≥18岁、体重指数≥30kg/m²且不愿接受减肥手术的女性患者。纳入了患有糖尿病、高血压、血脂异常和心血管疾病等肥胖相关合并症的患者。排除有减肥手术史以及有胃轻瘫、门静脉高压、肝硬化和凝血功能障碍临床表现的患者。主要研究结果是技术可行性和安全性，次要研究结果是术后1个月时的总体重减轻百分比、超重减轻百分比以及胃轻瘫临床症状指数的变化。
在内镜检查期间或之后立即未发生严重并发症。所有患者在头3天均出现上腹部疼痛、恶心和呕吐，1例患者在第二天出现轻度呕血，自行停止，内镜检查未发现异常。EBL术后1个月，平均超重减轻百分比和总体重减轻百分比分别为22.3%±9.9%和7.8%±2.5%。
EBL是一种有效且安全的肥胖管理干预措施。有必要进行更大队列的进一步研究，以全面评估EBL用于肥胖管理的长期疗效和安全性。
