McNaughton N
Department of Psychology, University of Otago, Dunedin, New Zealand.
Hippocampus. 2025 Jan;35(1):e23653. doi: 10.1002/hipo.23653.
This paper provides a personal history of work starting with the discovery that anxiolytic drugs reduce hippocampal theta frequency. It includes parallel work on septal elicitation of theta carried out in Jeffrey Gray's laboratory in Oxford; a statement of my original scientific perspective on the work; and a description of later work in my laboratory in New Zealand confirming the function of theta rhythmicity per se and its mediation of the effects of anxiolytic drugs on behavior. I finish with comments on risk management with such experiments and their use in larger scale theory development.
本文讲述了个人的工作经历，始于发现抗焦虑药物可降低海马体θ波频率。其中包括在牛津大学杰弗里·格雷实验室进行的关于隔区诱发θ波的平行研究；阐述了我对这项工作最初的科学观点；还描述了后来我在新西兰实验室开展的工作，该工作证实了θ节律本身的功能以及抗焦虑药物对行为影响的介导作用。最后，我对这类实验的风险管理及其在大规模理论发展中的应用发表了看法。
