Kene Rakshita Deepak, Desai Saloni, Rao Chetan, Dutta Majumder Parthopratim
Uvea Services, Sankara Nethralaya, Chennai, India.
Vitreoretinal Services, Sankara Nethralaya, Chennai, India.
Ocul Immunol Inflamm. 2025 Aug;33(6):1031-1034. doi: 10.1080/09273948.2024.2444512. Epub 2024 Dec 21.
To report a case of exudative retinal detachment (ERD) in a child with Acute retinal necrosis (ARN).
Retrospective Chart Review.
A six-year-old boy presented with anterior uveitis with hypopyon and exudative retinal detachment with peripheral confluent patches of retinitis in the left eye. Examination of the right eye was unremarkable. B scan ultrasonography of the left eye revealed moderate vitreous echoes along with a membrane in the inferior quadrant persisting on low gains indicating localised inferior retinal detachment with the presence of shifting fluid. Fundus examination under general anaesthesia failed to locate any break in the retina. Polymerase chain reaction from the aqueous aspirate was positive for Herpes Simplex Virus (HSV)-I. The child was treated with intravenous acyclovir three times a day, intravitreal injection of ganciclovir and subsequently started on oral steroids (0.5 mg/kg/day). While continuing antiviral treatment, dose of corticosteroid was gradually increased to 1 mg/kg/day. Intravenous injection of acyclovir for 28 days and six intravitreal injections with corticosteroid led to complete resolution of ERD. Six months after initial presentation, the patient underwent lens aspiration with intraocular lens (IOL) implantation under general anaesthesia, under antiviral coverage. Following surgery, his BCVA in the left eye improved to 6/12.
ERD is a rare complication of ARN, typically associated with HSV infection. Meticulous monitoring and combined systemic and local antiviral therapy, complemented by judicious corticosteroid use, are essential for managing such cases effectively.
报告一例患有急性视网膜坏死(ARN)的儿童发生渗出性视网膜脱离(ERD)的病例。
回顾性病历审查。
一名6岁男孩左眼出现前葡萄膜炎伴前房积脓以及渗出性视网膜脱离,周边有融合性视网膜病灶。右眼检查未见异常。左眼B超检查显示中等程度的玻璃体回声,以及下象限有一低增益下持续存在的膜,提示局部性视网膜脱离伴液性暗区。全身麻醉下的眼底检查未发现视网膜有任何裂孔。房水抽吸物的聚合酶链反应显示单纯疱疹病毒(HSV)-I阳性。该患儿接受每日3次静脉注射阿昔洛韦、玻璃体内注射更昔洛韦治疗,随后开始口服类固醇(0.5mg/kg/天)。在继续抗病毒治疗的同时,类固醇剂量逐渐增加至1mg/kg/天。静脉注射阿昔洛韦28天以及6次玻璃体内注射类固醇后,ERD完全消退。初次就诊6个月后,患者在抗病毒覆盖下于全身麻醉下行晶状体吸出联合人工晶状体(IOL)植入术。术后,他左眼的最佳矫正视力(BCVA)提高到了6/12。
ERD是ARN的一种罕见并发症,通常与HSV感染有关。细致的监测以及全身和局部联合抗病毒治疗,并辅以合理使用类固醇,对于有效管理此类病例至关重要。