Khazaei Mozafar, Meskaraf-Asadabadi Mohammadali, Khazaei Fatemeh, Kadivarian Sepide, Ghanbari Elham
Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Department of Tissue Engineering, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
J Drug Target. 2025 Jun;33(5):761-772. doi: 10.1080/1061186X.2024.2445744. Epub 2025 Jan 6.
Treating burn lesions has always been challenging because any product should be cheap, accessible, and have anti-bacterial commodities and tissue regeneration properties. The green synthesis of magnesium oxide nanoparticles (GS-MgONPs) can create an optimal prospect that is safe with low toxicity in biological tissue and better safety for application while including the antibacterial effect. This recent study aimed to evaluate the effectiveness of burn wound treatment using GS-MgONPs in rats. GS-MgONPs were synthesised for the first time using a Falcaria vulgaris extract (FVE) and characterised. Thirty male Wistar rats were divided into five groups: An untreated group, conventional product treated group, GS-MgONPs (1 wt%), GS-MgONPs (3 wt%) and 5. FVE (1 wt%). Treatments commenced immediately following burn induction and were administered daily for a duration of 21 d. GS-MgONPs showed a spherical morphology with a diameter of less than 100 nm. The NPs (1% and 3 wt%) and FVE demonstrated significant growth inhibition against Staphylococcus aureus while showing no cytotoxic effects on human fibroblast cells. The proposed subjects treated with 1 wt% and 3 wt% GS-MgONPs were able to significantly increase the rate of wound closure (p < 0.05). Histological observations revealed that collagen formation and epithelial regeneration were more pronounced in the groups receiving 1 wt% and 3 wt% MgONPs. These results indicate that GS-MgONPs effectively enhance the regeneration process.
治疗烧伤创面一直具有挑战性，因为任何产品都应价格低廉、易于获取，并具有抗菌性能和组织再生特性。氧化镁纳米颗粒的绿色合成（GS-MgONPs）可以创造一个最佳前景，即在生物组织中具有低毒性的安全性，在具有抗菌效果的同时应用安全性更高。这项最新研究旨在评估在大鼠中使用GS-MgONPs治疗烧伤创面的有效性。首次使用镰叶芹提取物（FVE）合成并表征了GS-MgONPs。将30只雄性Wistar大鼠分为五组：未治疗组、传统产品治疗组、GS-MgONPs（1 wt%）组、GS-MgONPs（3 wt%）组和FVE（1 wt%）组。烧伤诱导后立即开始治疗，每天给药，持续21天。GS-MgONPs呈球形形态，直径小于100 nm。纳米颗粒（1%和3 wt%）和FVE对金黄色葡萄球菌显示出显著的生长抑制作用，同时对人成纤维细胞无细胞毒性作用。用1 wt%和3 wt%的GS-MgONPs治疗的受试对象能够显著提高伤口愈合率（p < 0.05）。组织学观察表明，在接受1 wt%和3 wt% MgONPs的组中，胶原蛋白形成和上皮再生更为明显。这些结果表明，GS-MgONPs有效地促进了再生过程。
