杂合子家族性高胆固醇血症中的冠状动脉疾病与止血变量
Coronary artery disease and haemostatic variables in heterozygous familial hypercholesterolaemia.
作者信息
Sugrue D D, Trayner I, Thompson G R, Vere V J, Dimeson J, Stirling Y, Meade T W
出版信息
Br Heart J. 1985 Mar;53(3):265-8. doi: 10.1136/hrt.53.3.265.
Abstract
Haemostatic variables were measured in 61 patients with heterozygous familial hypercholesterolaemia, 32 of whom had evidence of coronary heart disease. Age adjusted mean concentrations of plasma fibrinogen and factor VIII were significantly higher in these patients than in the 29 patients without coronary heart disease, but there were no significant differences in serum lipid concentrations between the two groups. Comparisons in 30 patients taking and not taking lipid lowering drugs showed lower values for low density lipoprotein cholesterol, high density lipoprotein cholesterol and antithrombin III, and a higher high density lipoprotein ratio while receiving treatment. The results suggest that hypercoagulability may play a role in the pathogenesis of coronary heart disease in patients with familial hypercholesterolaemia.
摘要
对61例杂合子家族性高胆固醇血症患者进行了止血变量测量，其中32例有冠心病证据。这些患者经年龄校正后的血浆纤维蛋白原和凝血因子VIII平均浓度显著高于29例无冠心病的患者，但两组之间的血脂浓度无显著差异。对30例服用和未服用降脂药物的患者进行比较，结果显示接受治疗时低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和抗凝血酶III的值较低，而高密度脂蛋白比值较高。结果表明，高凝状态可能在家族性高胆固醇血症患者冠心病的发病机制中起作用。
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