Fang Yuju, Liu Yaqin, Huang Haibing, Zhang Guoxi, Zou Xiaofeng, Xie Tianpeng
The First Clinical College, Gannan Medical University, Ganzhou, China.
Department of Urology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Urolithiasis. 2024 Dec 21;53(1):10. doi: 10.1007/s00240-024-01681-1.
The purpose of this study is to address the gap in the existing literature regarding the risk factors for systemic inflammatory response syndrome (SIRS) in patients with a solitary kidney who undergo percutaneous nephrolithotomy (PCNL).This retrospective study reviewed the clinical data of 51 patients with solitary kidney stones who underwent PCNL from January 2018 to January 2024.The study evaluated demographic information, stone characteristics, and laboratory data. Among the 51 patients evaluated, 12 (23.5%) developed SIRS. Multivariate analysis showed that a high urinary white blood cell count (p = 0.041; OR, 1.004; 95% CI, 1.000-1.008), prolonged operation time (p = 0.040; OR, 1.054; 95% CI, 1.005-1.107), and postoperative blood leukocyte count (p = 0.031; OR, 1.459; 95% CI, 1.020-2.061) were independent risk factors for SIRS after PCNL in patients with a solitary kidney. Given the unique physiological conditions of patients with solitary kidneys, who face a higher incidence of kidney stones and have lower risk tolerance, the results of this study provide insights into the risk factors for SIRS after PCNL in these patients. By identifying these factors, clinicians can better stratify risk, implement preventive and therapeutic measures in a timely manner, reduce the risk of SIRS, and improve overall patient outcomes.
本研究的目的是填补现有文献中关于接受经皮肾镜取石术（PCNL）的单肾患者发生全身炎症反应综合征（SIRS）的危险因素方面的空白。这项回顾性研究回顾了2018年1月至2024年1月期间接受PCNL的51名单肾结石患者的临床资料。该研究评估了人口统计学信息、结石特征和实验室数据。在评估的51名患者中，12名（23.5%）发生了SIRS。多变量分析显示，高尿白细胞计数（p = 0.041；OR，1.004；95%CI，1.000 - 1.008）、手术时间延长（p = 0.040；OR，1.054；95%CI，1.005 - 1.107）和术后血白细胞计数（p = 0.031；OR，1.459；95%CI，1.020 - 2.061）是单肾患者PCNL术后发生SIRS的独立危险因素。鉴于单肾患者独特的生理状况，他们面临肾结石发病率较高且风险耐受性较低的情况，本研究结果为这些患者PCNL术后发生SIRS的危险因素提供了见解。通过识别这些因素，临床医生可以更好地分层风险，及时实施预防和治疗措施，降低SIRS的风险，并改善患者的总体预后。
