Roenigk H H, Gibstine C, Glazer S, Sparberg M, Yokoo H
Br J Dermatol. 1985 Jan;112(1):77-81. doi: 10.1111/j.1365-2133.1985.tb02294.x.
Twenty psoriatic patients treated with etretinate have been followed in a prospective study of liver biopsies. Twelve patients were followed up for 3 years, with four liver biopsies each. No significant damage to the liver was found during etretinate therapy. Etretinate may be stored in the fatty tissues of the liver or other body areas for prolonged periods.
在一项关于肝活检的前瞻性研究中,对20名接受依曲替酯治疗的银屑病患者进行了随访。12名患者随访了3年,每人进行了4次肝活检。在依曲替酯治疗期间未发现肝脏有明显损伤。依曲替酯可能会在肝脏或身体其他部位的脂肪组织中长期储存。