Chortatos Arthur, Vittersø Axel Davies, Uusitalo Lauri, Lehtonen Marko, Huotari Johanna, Auriola Seppo, Voutilainen Raimo, Backman Katri, Keski-Nisula Leea, Lehto Soili M
R&D department, Division of Mental Health Services, Akershus University Hospital, Lørenskog, Norway.
R&D department, Division of Mental Health Services, Akershus University Hospital, Lørenskog, Norway.
Psychoneuroendocrinology. 2025 Feb;172:107260. doi: 10.1016/j.psyneuen.2024.107260. Epub 2024 Dec 19.
To investigate the association prenatal maternal depression and anxiety may have on the levels of neonatal hair steroids (i.e. cortisol, cortisone, and the cortisol/cortisone ratio) at birth.
Altogether, 271 mother-infant pairs derived from the Finnish Kuopio Birth Cohort Study were assessed for maternal depression and anxiety using the Edinburgh Postnatal Depression Scale (EPDS: EPDS-10 for depression, EPDS-3A for anxiety) during the first (T1) and third (T3) trimesters. The levels of cortisol and cortisone were determined from neonatal hair samples obtained at birth. Linear mixed models adjusted for sex, preterm birth, smoking during pregnancy, and gestational diabetes were used.
Neither T1 nor T3 EPDS-10 predicted the levels of neonatal hair steroids. T3 EPDS-3A (p = 0.012), but not T1 EPDS-3A, was linked to reduced neonatal hair cortisol levels. Neither T1 nor T3 EPDS-3A were significant predictors of neonate cortisone levels or cortisol/cortisone ratios.
Prenatal maternal anxiety, but not depression, may lead to pronounced alterations in some markers of fetal stress systems. Future research should further determine whether prenatal maternal symptoms of anxiety would form an optimal intervention target in order to attenuate fetal stress responses.
研究产前母亲抑郁和焦虑与新生儿出生时头发类固醇水平（即皮质醇、可的松以及皮质醇/可的松比值）之间的关联。
在芬兰库奥皮奥出生队列研究中，共纳入271对母婴，在孕早期（T1）和孕晚期（T3）使用爱丁堡产后抑郁量表（EPDS：用于评估抑郁的EPDS - 10，用于评估焦虑的EPDS - 3A）对母亲的抑郁和焦虑情况进行评估。通过新生儿出生时采集的头发样本测定皮质醇和可的松水平。使用线性混合模型，并对性别、早产、孕期吸烟和妊娠期糖尿病进行校正。
T1和T3期的EPDS - 10均不能预测新生儿头发类固醇水平。T3期的EPDS - 3A（p = 0.012）与新生儿头发皮质醇水平降低有关，而T1期的EPDS - 3A则无此关联。T1和T3期的EPDS - 3A均不是新生儿可的松水平或皮质醇/可的松比值的显著预测指标。
产前母亲焦虑而非抑郁可能导致胎儿应激系统某些标志物的显著改变。未来研究应进一步确定产前母亲的焦虑症状是否会成为减轻胎儿应激反应的最佳干预靶点。
