Yang Juan, Yao Ying-Ling, Lv Xing-Yu, Geng Li-Hong, Wang Yue, Adu-Gyamfi Enoch Appiah, Wang Xue-Jiao, Qian Yue, Chen Ming-Xing, Zhong Zhao-Hui, Li Ren-Yan, Wan Qi, Ding Yu-Bin
Sichuan Jinxin Xinan Women & Children's Hospital, Chengdu 610011, Sichuan, China.
Department of Obstetrics and Gynecology, Women and Children's Hospital of Chongqing Medical University, Chongqing 401147, China; Joint International Research Laboratory of Reproduction and Development of the Ministry of Education of China, School of Public Health, Chongqing Medical University, Chongqing 400016, China.
Vaccine. 2025 Jan 25;45:126635. doi: 10.1016/j.vaccine.2024.126635. Epub 2024 Dec 20.
The safety of the COVID-19 inactivated vaccine on pregnancy outcomes in couples undergoing assisted reproductive technology remains uncertain due to limited and speculative evidence. Existing studies primarily focus on the vaccination status of females, with scant information available regarding the vaccination status of male partners. Moreover, there is minimal research tracking live birth outcomes.
OBJECTIVE(S): The objective of this study was to evaluate the impact of COVID-19 inactivated vaccine administration on the outcomes of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles in infertile couples in China.
This prospective cohort study involved couples undergoing IVF treatment at Sichuan Jinxin Xinan Women & Children's Hospital from August 2021 to September 2022. Based on whether they received vaccination before ovarian stimulation, the couples were divided into the vaccination group and the non-vaccination group. We compared the laboratory parameters and pregnancy outcomes between the two groups.
After performing propensity score matching (PSM), we observed similar live birth rates (41.23% vs. 44.08%, P = 0.555), clinical pregnancy rates (52.61% vs. 54.98%, P = 0.625), biochemical pregnancy (62.56% vs. 63.98%, P = 0.762), and ongoing pregnancy rates (49.76% vs. 51.18%, P = 0.770) between the vaccinated and unvaccinated women. Also, no significant disparities were found in terms of embryo development and laboratory parameters between the groups. Moreover, male vaccination had no impact on patients' pregnancy outcomes in assisted reproductive technology (ART) treatments (all P > 0.05). Additionally, there were no observable effects of vaccination on embryo development and pregnancy outcomes among couples undergoing ART (all P > 0.05).
CONCLUSION(S): The findings suggest that COVID-19 vaccination did not have a significant effect on patients undergoing IVF/ICSI with fresh embryo transfer. Therefore, it is recommended that couples should receive COVID-19 vaccination as scheduled to help mitigate the COVID-19 pandemic.
由于证据有限且具有推测性，新冠病毒灭活疫苗对接受辅助生殖技术的夫妇妊娠结局的安全性仍不确定。现有研究主要关注女性的疫苗接种状况，关于男性伴侣的疫苗接种状况的信息很少。此外，跟踪活产结局的研究极少。
本研究的目的是评估在中国不孕夫妇中接种新冠病毒灭活疫苗对体外受精（IVF）和卵胞浆内单精子注射（ICSI）周期结局的影响。
这项前瞻性队列研究纳入了2021年8月至2022年9月在四川锦欣西南妇女儿童医院接受IVF治疗的夫妇。根据他们在卵巢刺激前是否接种疫苗，将夫妇分为接种组和未接种组。我们比较了两组之间的实验室参数和妊娠结局。
进行倾向评分匹配（PSM）后，我们观察到接种疫苗和未接种疫苗的女性之间的活产率（41.23%对44.08%，P = 0.555）、临床妊娠率（52.61%对54.98%，P = 0.625）、生化妊娠率（62.56%对63.98%，P = 0.762）和持续妊娠率（49.76%对51.18%，P = 0.770）相似。此外，两组之间在胚胎发育和实验室参数方面未发现显著差异。此外，男性接种疫苗对辅助生殖技术（ART）治疗中患者的妊娠结局没有影响（所有P>0.05）。此外，接种疫苗对接受ART的夫妇的胚胎发育和妊娠结局没有可观察到的影响（所有P>0.05）。
研究结果表明，新冠病毒疫苗接种对接受新鲜胚胎移植的IVF/ICSI患者没有显著影响。因此，建议夫妇应按计划接种新冠病毒疫苗，以帮助减轻新冠疫情。
