Talbot Aimee, de Koning-Ward Tania F, Layton Daniel
CSIRO, Health and Biosecurity, Australian Centre for Disease Preparedness, Geelong, Victoria, Australia; School of Medicine, Deakin University, Geelong, Victoria, Australia; Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Victoria, Australia.
School of Medicine, Deakin University, Geelong, Victoria, Australia; Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Victoria, Australia.
Vaccine. 2025 Jan 25;45:126648. doi: 10.1016/j.vaccine.2024.126648. Epub 2024 Dec 20.
Vaccines and diagnostic tools stand out as among the most influential advancements in public health, credited with averting an estimated 6 million deaths annually and substantially alleviating the burden of infectious disease. Despite this progress, the global imperative to prevent, detect, and combat infectious disease persists. Regrettably, hundreds of thousands of lives are still lost due to inadequate access to vaccines and diagnostics. A critical obstacle in accessibility lies in the requirement of reliable cold chain for their transportation and storage, a resource that remains inadequate in many regions, particularly in the developing world. Various factors, including socio-economic disparities, biological complexities, and manufacturing processes, exert significant influence on the availability and integrity of vaccines and diagnostic materials. This review aims to explore the multifaceted issue of inequality in access to disease control tools, examining the vulnerabilities of vaccines and diagnostics while also investigating recent advancements that offer promising solutions to improve thermal stability.
疫苗和诊断工具是公共卫生领域最具影响力的进步之一，据信每年可避免约600万人死亡，并大幅减轻传染病负担。尽管取得了这一进展，但全球预防、检测和抗击传染病的紧迫性依然存在。遗憾的是，由于无法充分获得疫苗和诊断工具，仍有数十万人丧生。可及性的一个关键障碍在于其运输和储存需要可靠的冷链，而在许多地区，尤其是发展中世界，这种资源仍然不足。包括社会经济差距、生物学复杂性和制造工艺在内的各种因素，对疫苗和诊断材料的供应和完整性产生重大影响。本综述旨在探讨获取疾病控制工具方面不平等这一多方面问题，研究疫苗和诊断工具的脆弱性，同时调查近期取得的进展，这些进展为提高热稳定性提供了有前景的解决方案。
