人体同时接触甲苯和对二甲苯：中枢神经功能
Coexposure to toluene and p-xylene in man: central nervous functions.
作者信息
Olson B A, Gamberale F, Iregren A
出版信息
Br J Ind Med. 1985 Feb;42(2):117-22. doi: 10.1136/oem.42.2.117.
Abstract
Sixteen men were studied in an exposure chamber to assess the effect of four hours' exposure to toluene (3.25 mmol/m3), xylene (2.84 mmol/m3), a mixture of toluene and xylene (2.20 + 0.94 mmol/m3), and a control condition. With the aid of microcomputers, subjects performed tests of simple reaction time, short term memory, and choice reaction time immediately after entering the chamber, after two, and after four hours' exposure. The results indicate that the performance on the tests was unaffected by exposure. In the light of this result the risk of an acute effect on central nervous functions after exposure for four hours at concentrations that do not exceed the Swedish threshold limit values was considered to be minimal.
摘要
16名男性在暴露舱中接受研究，以评估接触甲苯（3.25毫摩尔/立方米）、二甲苯（2.84毫摩尔/立方米）、甲苯与二甲苯混合物（2.20 + 0.94毫摩尔/立方米）4小时以及处于对照条件下的影响。借助微型计算机，受试者在进入舱室后、接触2小时后以及接触4小时后，立即进行简单反应时间、短期记忆和选择反应时间测试。结果表明，测试表现不受接触影响。鉴于这一结果，在不超过瑞典阈限值的浓度下接触4小时后，对中枢神经功能产生急性影响的风险被认为极小。
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