Zhang Maoxing, Wang Qingyu, Wang Ying
Basic School of Medicine, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 260071, China.
Department of Anesthesiology, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
Neurochem Int. 2025 Feb;183:105921. doi: 10.1016/j.neuint.2024.105921. Epub 2024 Dec 19.
The central endocannabinoid (eCB) system in brain shows a crucial role in the regulation of feeding behaviors, influencing both metabolic and non-metabolic mechanisms of appetite control, which has been paid much attention. Although there are already many review articles discussing eCB modulation of feeding behaviors, our paper attempts to summarize the recent advancements through synapses, circuits, and network in brain. Our focus is on the dual role of eCB signalling in regulating metabolic energy balance and hedonic reward-related feeding. In the context of metabolic regulation of feeding behaviors, eCBs affect the hypothalamic circuits that balance hunger and satiety through signal integration related to energy status and nutrient availability. Dysregulation of this system can contribute to metabolic disorders such as obesity and anorexia. In non-metabolic feeding, the eCB system influences the hedonic aspects of eating by modulating reward pathways, including the mesolimbic system and the olfactory bulb, critical for motivating food intake and processing sensory cues. This review also explores therapeutic strategies targeting the eCB system, including cannabinoid receptor antagonists and eCB hydrolase enzyme inhibitors, which hold promise for treating conditions associated with appetite dysregulation and eating disorders. By synthesizing recent findings, we aim to highlight the intricate mechanisms through which the eCB system affects feeding behavior and to propose future directions for research and therapeutic intervention in the realm of appetite control and eating disorders.
大脑中的内源性大麻素（eCB）系统在调节进食行为中起着关键作用，影响着食欲控制的代谢和非代谢机制，这一点已备受关注。尽管已有许多综述文章讨论了eCB对进食行为的调节作用，但我们的论文试图通过大脑中的突触、神经回路和网络来总结近期的进展。我们关注的是eCB信号在调节代谢能量平衡和与享乐奖赏相关的进食方面的双重作用。在进食行为的代谢调节背景下，eCB通过与能量状态和营养物质可用性相关的信号整合，影响平衡饥饿和饱腹感的下丘脑神经回路。该系统的失调会导致肥胖和厌食等代谢紊乱。在非代谢性进食中，eCB系统通过调节奖赏通路，包括中脑边缘系统和嗅球，影响进食的享乐方面，这些对激发食物摄入和处理感官线索至关重要。本综述还探讨了针对eCB系统的治疗策略，包括大麻素受体拮抗剂和eCB水解酶抑制剂，这些策略有望治疗与食欲失调和饮食紊乱相关的疾病。通过综合近期的研究结果，我们旨在突出eCB系统影响进食行为的复杂机制，并为食欲控制和饮食紊乱领域的研究及治疗干预提出未来方向。
