睡眠质量差与社区居住的老年人可能存在的肌肉减少症相关：长寿体检（LOOKUP）8的结果

Poor sleep quality is associated with probable sarcopenia in community-dwelling older adults: Results from the longevity check-up (lookup) 8.

作者信息

Cacciatore Stefano, Calvani Riccardo, Mancini Jasmine, Ciciarello Francesca, Galluzzo Vincenzo, Tosato Matteo, Marzetti Emanuele, Landi Francesco

机构信息

Department of Geriatrics, Orthopedics and Rheumatology, Università Cattolica del Sacro Cuore, L.go F. Vito 1, 00168 Rome, Italy; Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, L.go A. Gemelli 8, 00168 Rome, Italy.

出版信息

Exp Gerontol. 2025 Feb;200:112666. doi: 10.1016/j.exger.2024.112666. Epub 2024 Dec 28.

DOI:10.1016/j.exger.2024.112666

PMID:39709067

Abstract

BACKGROUND

Poor sleep quality may contribute to sarcopenia, but evidence remains sparse. This retrospective cross-sectional study investigated the association between subjective sleep quality and probable sarcopenia in a cohort of community-dwelling older adults enrolled in the Longevity Check-Up 8+ study.

METHODS

Participants were asked about their sleep quality over the past month, with four possible options ("very good", "quite good", "quite bad", very bad"). For the analysis, participants were grouped into good or bad sleep quality categories. Probable sarcopenia was operationalized according to handgrip strength values < 27 kg for men and < 16 kg for women. Logistic regression models were used to explore the relationship between sleep quality and probable sarcopenia.

RESULTS

1971 participants were included in the analysis (mean age 73.4 ± 6.2 years, 50.0 % women). Bad sleep quality was reported by 28.3 % of participants and was more prevalent among women, physically inactive individuals, and those with dyslipidemia. Probable sarcopenia was more prevalent in participants with bad sleep quality (23.8 % vs. 18.7 %, p = 0.012). Logistic regression revealed that bad sleep quality was significantly associated with increased odds of probable sarcopenia in both unadjusted (odds ratio [OR] 1.36, 95 % confidence interval [CI] 1.07-1.72, p = 0.010) and fully adjusted models (OR 1.40, 95 % CI 1.08-1.81, p = 0.011).

CONCLUSIONS

Poor sleep quality is associated with increased likelihood of probable sarcopenia in older adults. This finding highlights the importance of addressing sleep quality in interventions aimed at preventing sarcopenia and promoting healthy aging.

摘要

背景

睡眠质量差可能导致肌肉减少症，但相关证据仍然稀少。这项回顾性横断面研究调查了参加“长寿8+体检”研究的社区老年人群中主观睡眠质量与可能的肌肉减少症之间的关联。

方法

询问参与者过去一个月的睡眠质量，有四个可能的选项（“非常好”、“相当好”、“相当差”、“非常差”）。在分析中，将参与者分为睡眠质量好或差两类。根据男性握力值<27千克和女性握力值<16千克来定义可能的肌肉减少症。使用逻辑回归模型来探讨睡眠质量与可能的肌肉减少症之间的关系。

结果

1971名参与者纳入分析（平均年龄73.4±6.2岁，50.0%为女性）。28.3%的参与者报告睡眠质量差，在女性、身体不活动的个体以及患有血脂异常的人群中更为普遍。睡眠质量差的参与者中可能的肌肉减少症更为普遍（23.8%对18.7%，p = 0.012）。逻辑回归显示，在未调整模型（优势比[OR]1.36，95%置信区间[CI]1.07 - 1.72，p = 0.010）和完全调整模型（OR 1.40，95%CI 1.08 - 1.81，p = 0.011）中，睡眠质量差均与可能的肌肉减少症几率增加显著相关。