Zhang Shijiao, Zhang Feifei, Chen Hong, Wang Lei, Jiang Xiaolian
West China School of Nursing (S.Z., X.J.), Sichuan University/West China Hospital, Sichuan University, Chengdu, China.
Shanghai Jiao Tong University School of Nursing (F.Z.), Shanghai, China.
J Pain Symptom Manage. 2025 Apr;69(4):331-342. doi: 10.1016/j.jpainsymman.2024.12.013. Epub 2024 Dec 19.
Cancer-related fatigue (CRF) can affect patients undergoing chemotherapy severely. A comprehensive intervention targeted for reducing CRF is lacking.
To evaluate the effectiveness of an innovative multifaceted web-based patient-empowered CRF management program for improving CRF, perceived self-efficacy for fatigue self-management (PSEFSM), physical activity, quality of sleep, anxiety, depression, pain and quality of life (QoL) among gastric cancer patients undergoing chemotherapy in China.
A total of 92 eligible gastric cancer patients undergoing chemotherapy were recruited and randomly assigned to two groups. Participants in the intervention group received a 12-week CRF intervention including eight online sessions, patient diary for self-management practice; telephone follow-up and online support via WeChat. The control group received routine care. Primary outcome was CRF. Secondary outcomes included PSEFSM, physical activity, quality of sleep, anxiety, depression, pain, and QoL. Outcome variables were measured three times: at admission(T0), post-intervention(T1) and one-month post-intervention(T2). Repeated measures ANOVA or generalized estimating equations were used to evaluate the intervention effect.
Significant group by time interaction was found in the scores of total CRF and its three dimensions, PSEFSM, total physical activities, quality of sleep, anxiety, depression, and QoL of the two groups (P <0.05). No significant difference was found in pain scores (P >0.05).
This study provides evidence that an innovative multifaceted web-based patient-empowered CRF management program is effective in reducing CRF and improving related symptoms (depression, anxiety, quality of sleep), physical activity, PSEFSM and QoL for gastric cancer patients undergoing chemotherapy.
癌症相关疲劳（CRF）会严重影响接受化疗的患者。目前缺乏针对减轻CRF的综合干预措施。
评估一项创新的多方面基于网络的患者自主CRF管理项目对改善中国接受化疗的胃癌患者的CRF、疲劳自我管理的感知自我效能（PSEFSM）、身体活动、睡眠质量、焦虑、抑郁、疼痛和生活质量（QoL）的有效性。
共招募了92名符合条件的接受化疗的胃癌患者，并随机分为两组。干预组的参与者接受为期12周的CRF干预，包括八次在线课程、用于自我管理实践的患者日记；电话随访和通过微信的在线支持。对照组接受常规护理。主要结局是CRF。次要结局包括PSEFSM、身体活动、睡眠质量、焦虑、抑郁、疼痛和QoL。结局变量在三个时间点进行测量：入院时（T0）、干预后（T1）和干预后一个月（T2）。采用重复测量方差分析或广义估计方程来评估干预效果。
两组在总CRF及其三个维度、PSEFSM、总身体活动、睡眠质量、焦虑、抑郁和QoL的得分上存在显著的组间时间交互作用（P<0.05）。疼痛得分无显著差异（P>0.05）。
本研究提供了证据，表明一项创新的多方面基于网络的患者自主CRF管理项目在减轻接受化疗的胃癌患者的CRF并改善相关症状（抑郁、焦虑、睡眠质量）、身体活动、PSEFSM和QoL方面是有效的。
