Bredberg A, Söderhäll S
Biochim Biophys Acta. 1985 Mar 20;824(3):268-71. doi: 10.1016/0167-4781(85)90058-2.
Treatment of normal and xeroderma pigmentosum complementation group E skin fibroblasts with 8-methoxypsoralen plus repeated doses of near-ultraviolet radiation elicited a marked increase in DNA strand breakage during a subsequent incubation. No such induction of breaks was noted with cells from xeroderma pigmentosum groups A and D. The results suggest that the gene product which is deficient in xeroderma pigmentosum group E cells is involved in a critical step of DNA repair of far-ultraviolet photoproducts but not so in the repair of psoralen cross-links.
用8-甲氧基补骨脂素加重复剂量的近紫外线辐射处理正常皮肤成纤维细胞和着色性干皮病E互补组皮肤成纤维细胞，在随后的培养过程中会引起DNA链断裂显著增加。而着色性干皮病A组和D组细胞未观察到这种断裂诱导现象。结果表明，着色性干皮病E组细胞中缺乏的基因产物参与了远紫外线光产物DNA修复的关键步骤，但在补骨脂素交联修复中并非如此。
