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MiR-34a regulates renal circadian rhythms during cisplatin-induced nephrotoxicity.

作者信息

Abdalla Mohnad, El-Arabey Amr Ahmed, Gai Zhongtao

机构信息

Research Institute of Pediatrics, Children's Hospital Affiliated to Shandong University (Jinan Children's Hospital), Jinan, China.

Center of Bee Research and Its Products, King Khalid University, P. O. Box 9004, 61413, Abha, Saudi Arabia.

出版信息

Hum Cell. 2024 Dec 22;38(1):32. doi: 10.1007/s13577-024-01163-x.

DOI:10.1007/s13577-024-01163-x
PMID:39709581
Abstract
摘要

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MiR-34a regulates renal circadian rhythms during cisplatin-induced nephrotoxicity.微小RNA-34a在顺铂诱导的肾毒性过程中调节肾脏昼夜节律。
Hum Cell. 2024 Dec 22;38(1):32. doi: 10.1007/s13577-024-01163-x.
2
MicroRNA-34a is induced via p53 during cisplatin nephrotoxicity and contributes to cell survival.miRNA-34a 在顺铂肾毒性中通过 p53 诱导，并有助于细胞存活。
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3
Renal circadian clock regulates the dosing-time dependency of cisplatin-induced nephrotoxicity in mice.肾脏生物钟调控顺铂诱导的小鼠肾毒性的给药时间依赖性。
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2.4 GHz Electromagnetic Field Influences the Response of the Circadian Oscillator in the Colorectal Cancer Cell Line DLD1 to miR-34a-Mediated Regulation.2.4GHz 电磁场影响结直肠癌细胞系 DLD1 中昼夜振荡器对 miR-34a 介导调控的反应。
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PPAR-α Deletion Attenuates Cisplatin Nephrotoxicity by Modulating Renal Organic Transporters MATE-1 and OCT-2.过氧化物酶体增殖物激活受体-α缺失通过调节肾脏有机转运体 MATE-1 和 OCT-2 减轻顺铂肾毒性。
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本文引用的文献

1
miR34a-5p impedes CLOCK expression in chronodisruptive C57BL/6J mice and potentiates pro-atherogenic manifestations.miR34a-5p 抑制了时钟紊乱的 C57BL/6J 小鼠中的 CLOCK 表达，并增强了动脉粥样硬化前的表现。
PLoS One. 2023 Aug 10;18(8):e0283591. doi: 10.1371/journal.pone.0283591. eCollection 2023.
2
Dihydrotestosterone as mediator for cisplatin induced nephrotoxicity: New insight down the road.二氢睾酮作为顺铂诱导肾毒性的介质：新的研究进展
Toxicology. 2017 Jul 15;387:108. doi: 10.1016/j.tox.2017.05.020. Epub 2017 Jun 3.
3
Effect of miR-34a in regulating steatosis by targeting PPARα expression in nonalcoholic fatty liver disease.
miR-34a通过靶向非酒精性脂肪性肝病中PPARα的表达来调节脂肪变性的作用。
Sci Rep. 2015 Sep 2;5:13729. doi: 10.1038/srep13729.
4
Tubular p53 regulates multiple genes to mediate AKI.肾小管p53调节多个基因以介导急性肾损伤。
J Am Soc Nephrol. 2014 Oct;25(10):2278-89. doi: 10.1681/ASN.2013080902. Epub 2014 Apr 3.
5
Renal circadian clock regulates the dosing-time dependency of cisplatin-induced nephrotoxicity in mice.肾脏生物钟调控顺铂诱导的小鼠肾毒性的给药时间依赖性。
Mol Pharmacol. 2014 May;85(5):715-22. doi: 10.1124/mol.113.089805. Epub 2014 Feb 24.
6
MicroRNA-34a is induced via p53 during cisplatin nephrotoxicity and contributes to cell survival.miRNA-34a 在顺铂肾毒性中通过 p53 诱导，并有助于细胞存活。
Mol Med. 2010 Sep-Oct;16(9-10):409-16. doi: 10.2119/molmed.2010.00002. Epub 2010 Apr 9.
7
Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions.有机阳离子转运体 2 介导顺铂诱导的耳肾毒性，是保护性干预的靶点。
Am J Pathol. 2010 Mar;176(3):1169-80. doi: 10.2353/ajpath.2010.090610. Epub 2010 Jan 28.
8
Alpha-lipoic acid attenuates cisplatin-induced acute kidney injury in mice by suppressing renal inflammation.α-硫辛酸通过抑制肾脏炎症减轻顺铂诱导的小鼠急性肾损伤。
Nephrol Dial Transplant. 2009 Oct;24(10):3012-20. doi: 10.1093/ndt/gfp242. Epub 2009 May 27.
9
Light-induced degradation of TIMELESS and entrainment of the Drosophila circadian clock.光诱导的TIMELESS降解与果蝇生物钟的同步化
Science. 1996 Mar 22;271(5256):1736-40. doi: 10.1126/science.271.5256.1736.