Kn Sandeepa, Shetty Shilpa S, Shetty Prasannakumar
Nitte (Deemed To Be University), KS Hegde Medical Academy (KSHEMA), Central Research Laboratory, Cellomics, Lipidomics and Molecular Genetics Division, India.
Nitte (Deemed To Be University), KS Hegde Medical Academy (KSHEMA), Central Research Laboratory, Cellomics, Lipidomics and Molecular Genetics Division, India.
Pathol Res Pract. 2025 Feb;266:155772. doi: 10.1016/j.prp.2024.155772. Epub 2024 Dec 15.
Uterine Fibroids (UF) are the most common (about 70 % cases) benign gynecological smooth muscle tumors of the uterus in women of reproductive age, characterized by abnormal cholesterol, lipoproteins, and triglyceride levels, and are a major public health concern. Despite its high prevalence, this condition remains complex and poorly understood. These tumors are hormone-dependent and hormones and lipid levels are inversely related. This review delves into the existing literature and critically evaluates studies that explore the potential relationship between lipids in the pathogenesis of uterine fibroids. This review concludes by critically appraising the research gaps in the involvement of lipids and signaling pathways in the pathogenesis of uterine fibroids and future directions for investigating this intriguing biological connection. By elucidating the potential link between uterine fibroids and lipids, this review paves the way for an improved understanding of fibroid pathogenesis, personalized risk assessment, and novel lipid-lowering therapeutic strategies.
子宫肌瘤（UF）是育龄期女性最常见的（约占70%的病例）子宫良性妇科平滑肌肿瘤，其特征是胆固醇、脂蛋白和甘油三酯水平异常，是一个重大的公共卫生问题。尽管其患病率很高，但这种情况仍然复杂且了解甚少。这些肿瘤依赖激素，激素和脂质水平呈负相关。本综述深入研究了现有文献，并批判性地评估了探索脂质在子宫肌瘤发病机制中的潜在关系的研究。本综述通过批判性地评估脂质和信号通路在子宫肌瘤发病机制中的研究空白以及研究这一有趣生物学联系的未来方向来得出结论。通过阐明子宫肌瘤与脂质之间的潜在联系，本综述为更好地理解肌瘤发病机制、个性化风险评估和新型降脂治疗策略铺平了道路。
