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重症监护病房危重症患者念珠菌血症诊断与治疗的循证临床标准

Evidence-based clinical standard for the diagnosis and treatment of candidemia in critically ill patients in the intensive care unit.

作者信息

Cortés Jorge Alberto, Valderrama-Rios Martha Carolina, Peçanha-Pietrobom Paula M, Júnior Moacyr Silva, Diaz-Brochero Cándida, Robles-Torres Rafael Ricardo, Espinosa-Almanza Carmelo José, Nocua-Báez Laura Cristina, Nucci Marcio, Álvarez-Moreno Carlos Arturo, Queiroz-Telles Flavio, Rabagliati Ricardo, Rojas-Fermín Rita, Finquelievich Jorge L, Riera Fernando, Cornejo-Juárez Patricia, Corzo-León Dora E, Cuéllar Luis E, Zurita Jeannete, Hernández Augusto Raúl, Colombo Arnaldo Lopes

机构信息

Universidad Nacional de Colombia, Facultad de Medicina, Departamento de Medicina Interna, Bogotá, Colombia; Hospital Universitario Nacional de Colombia, Unidad de Infectología, Bogotá, Colombia.

Universidad Nacional de Colombia, Facultad de Medicina, Departamento de Medicina Interna, Bogotá, Colombia; Hospital Universitario Nacional de Colombia, Unidad de Infectología, Bogotá, Colombia.

出版信息

Braz J Infect Dis. 2025 Jan-Feb;29(1):104495. doi: 10.1016/j.bjid.2024.104495. Epub 2024 Dec 21.

DOI:10.1016/j.bjid.2024.104495
PMID:39709887
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11846572/
Abstract

Candidemia is the predominant form of invasive candidiasis and the most frequently occurring serious fungal infection in critically ill patients in Intensive Care Units (ICU). Studies carried out in Latin America reveal a higher incidence of candidemia and higher mortality rates when compared to North America or Europe. This highlights the need to develop guidelines for correctly diagnosing and treating candidemia in critically ill patients in the ICU. These guidelines are part of the efforts to implement antifungal optimization programs in the region to obtain better clinical outcomes and promote rational antifungal use. This evidence-based clinical standard, established through expert consensus for the Latin American context, contains recommendations and algorithms for diagnosing and treating candidemia in critically ill ICU patients.

摘要

念珠菌血症是侵袭性念珠菌病的主要形式，也是重症监护病房（ICU）中危重症患者最常发生的严重真菌感染。在拉丁美洲开展的研究表明，与北美或欧洲相比，念珠菌血症的发病率更高，死亡率也更高。这凸显了制定ICU危重症患者念珠菌血症正确诊断和治疗指南的必要性。这些指南是该地区实施抗真菌优化项目以获得更好临床结果并促进合理使用抗真菌药物所做努力的一部分。这项基于证据的临床标准是通过拉丁美洲背景下的专家共识制定的，包含了ICU危重症患者念珠菌血症诊断和治疗的建议及算法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5b3/11846572/de16e6b35c39/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5b3/11846572/980f6393426d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5b3/11846572/82d2b480d454/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5b3/11846572/ba360aa347b7/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5b3/11846572/de16e6b35c39/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5b3/11846572/980f6393426d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5b3/11846572/82d2b480d454/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5b3/11846572/ba360aa347b7/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5b3/11846572/de16e6b35c39/gr4.jpg

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本文引用的文献

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Mortality Caused by Bloodstream Infections in Comparison with Other Candida Species, a Multicentre Retrospective Cohort.与其他念珠菌属相比，血流感染导致的死亡率：一项多中心回顾性队列研究
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