单纯疱疹溶瘤病毒治疗恶性胶质瘤及其递送机制
Herpes Simplex Oncolytic Viral Therapy for Malignant Glioma and Mechanisms of Delivery.
作者信息
Erickson Nicholas J, Stavarache Mihaela, Tekedereli Ibrahim, Kaplitt Michael G, Markert James M
机构信息
Department of Neurosurgery, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Laboratory of Molecular Neurosurgery, Department of Neurological Surgery, Weill Cornell Medicine, New York, New York, USA.
出版信息
World Neurosurg. 2025 Feb;194:123595. doi: 10.1016/j.wneu.2024.123595. Epub 2025 Jan 23.
The authors present a comprehensive review on the history and development of oncolytic herpes simplex viral therapies for malignant glioma with a focus on mechanisms of delivery in prior and ongoing clinical trials. This review highlights the advancements made with regard to delivering these therapies to a highly complex immunologic environment in the setting of the blood-brain and blood-tumor barrier in a safe and effective manner.
作者对溶瘤单纯疱疹病毒治疗恶性胶质瘤的历史与发展进行了全面综述，重点关注既往及正在进行的临床试验中的递送机制。本综述强调了在血脑屏障和血肿瘤屏障环境下，以安全有效的方式将这些疗法递送至高度复杂免疫环境方面所取得的进展。
Zotero 插件