Zhou Qi, Song Lina, Ma Jiahui, Tang Danyi, Qi Qing, Sun Hongmei, Du Yan, Wang Ling
Department of Gynecology, Yangpu District Hospital of Traditional Chinese Medicine, Shanghai, China.
Clinical Research Unit, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Drug Discov Ther. 2025 Jan 14;18(6):362-367. doi: 10.5582/ddt.2024.01079. Epub 2024 Dec 21.
Acupuncture and traditional Chinese medicine (TCM) have shown certain benefits in assisted in vitro fertilization and embryo transfer (IVF-ET). In this study, we evaluated the efficacy and safety of the combination of acupuncture combined with the Bushen Quyu decoction in patients with failures of IVF-ET. This study was conducted at Shanghai Yangpu District Hospital of TCM from May to November of 2021. Patients with failed IVF-ET received either combined therapy or the routine procedure (control group). The main outcomes were implantation rate and clinical pregnancy rate. Radioimmunoassay was used to detect serum levels of estradiol (E2) and progesterone on the day of injection of human chorionic gonadotropin (hCG). The endometrial thickness, resistance index (RI), and pulsatility index (PI) of bilateral uterine arteries were measured by color Doppler ultrasound. Safety was assessed in all participants. After 3 months of treatment, the implantation rate (61.9% vs. 47.7%, P = 0.187) and clinical pregnancy rate (52.4% vs. 36.4%, P = 0.135) of patients with IVF-ET failure receiving acupuncture therapy combined with Bushen Quyu decoction appeared to be higher than those of the routine procedure group, although the increase was not statistically significant. However, the serum E2 level and endometrial thickness of patients in the combined therapy group increased significantly than those of the control group after hCG injection. The RI and PI values of bilateral uterine arteries in the combined therapy group were significantly lower than those in the control group after hCG injection. No difference of adverse events was observed between combined therapy group and control group (11.9% vs. 11.36%, P = 0.962). Acupuncture therapy combined with TCM treatment may improve endometrial receptivity and hormone secretion, and increase uterine artery blood flow.
针灸和传统中医（TCM）在辅助体外受精和胚胎移植（IVF-ET）中已显示出一定益处。在本研究中，我们评估了针灸联合补肾祛瘀汤对IVF-ET失败患者的疗效和安全性。本研究于2021年5月至11月在上海杨浦区中医医院进行。IVF-ET失败的患者接受联合治疗或常规程序（对照组）。主要结局指标为着床率和临床妊娠率。采用放射免疫分析法检测注射人绒毛膜促性腺激素（hCG）当天的血清雌二醇（E2）和孕酮水平。通过彩色多普勒超声测量双侧子宫动脉的内膜厚度、阻力指数（RI）和搏动指数（PI）。对所有参与者进行安全性评估。治疗3个月后，接受针灸联合补肾祛瘀汤治疗的IVF-ET失败患者的着床率（61.9%对47.7%，P = 0.187）和临床妊娠率（52.4%对36.4%，P = 0.135）似乎高于常规程序组，尽管升高无统计学意义。然而，联合治疗组患者在hCG注射后的血清E2水平和内膜厚度显著高于对照组。联合治疗组在hCG注射后双侧子宫动脉的RI和PI值显著低于对照组。联合治疗组与对照组之间未观察到不良事件差异（11.9%对11.36%，P = 0.962）。针灸联合中医治疗可能改善子宫内膜容受性和激素分泌，并增加子宫动脉血流量。
