文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期,新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

针灸作为增强女性不孕症子宫内膜容受性的辅助疗法:文献综述

Acupuncture as an adjunct therapy for enhancing endometrial receptivity in female infertility: a literature review.

作者信息

Zhang Shike, He Hui, Wang Jingyuan, Ma Li, Wei Xiaoyu, Zhang Mingxing, Guo Yi

机构信息

Research Center of Experimental Acupuncture, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China.

出版信息

Front Physiol. 2025 Aug 7;16:1548737. doi: 10.3389/fphys.2025.1548737. eCollection 2025.


DOI:10.3389/fphys.2025.1548737
PMID:40852463
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12368429/
Abstract

Infertility remains a global challenge, with female factors accounting for the majority of cases. Endometrial receptivity (ER), the ability of the endometrium to accept and support embryo implantation, is a critical determinant of successful conception. Traditional Chinese medicine, specifically acupuncture, has been widely adopted as an adjunct therapy for enhancing ER and improving reproductive outcomes in infertile women. This literature review explores the efficacy and underlying mechanisms of acupuncture in promoting ER by focusing on key areas, including improvements in endometrial morphology, increasing uterine blood flow, adjustment to hormone levels, regulation of molecular markers, modulating endometrial immune-inflammatory microenvironment, and probably activating the somatosensory-autonomic reflex pathway. Although promising, existing studies on acupuncture and ER often face limitations in sample size and methodological rigor, highlighting the need for larger, high-quality randomized controlled trials (RCT). Furthermore, the safety profile of acupuncture in infertility treatment is favorable, with few reported adverse effects. These findings suggest that acupuncture could be a viable complementary therapy for improving pregnancy outcomes in women with compromised ER, although further research is essential to establish definitive protocols and mechanisms.

摘要

不孕症仍然是一项全球性挑战,其中女性因素占大多数病例。子宫内膜容受性(ER),即子宫内膜接受并支持胚胎着床的能力,是成功受孕的关键决定因素。传统中医,特别是针灸,已被广泛用作辅助疗法,以增强子宫内膜容受性并改善不孕女性的生殖结局。这篇文献综述通过关注关键领域,探讨了针灸促进子宫内膜容受性的疗效和潜在机制,包括改善子宫内膜形态、增加子宫血流量、调节激素水平、调控分子标志物、调节子宫内膜免疫炎症微环境以及可能激活躯体感觉 - 自主反射通路。尽管前景乐观,但现有关于针灸与子宫内膜容受性的研究在样本量和方法严谨性方面往往存在局限性,这凸显了开展更大规模、高质量随机对照试验(RCT)的必要性。此外,针灸在不孕症治疗中的安全性良好,报告的不良反应很少。这些发现表明,针灸可能是改善子宫内膜容受性受损女性妊娠结局的一种可行的辅助疗法,不过,进一步的研究对于确定明确的方案和机制至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cc8/12368429/99bc327cb63f/fphys-16-1548737-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cc8/12368429/397e6f83803d/fphys-16-1548737-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cc8/12368429/99bc327cb63f/fphys-16-1548737-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cc8/12368429/397e6f83803d/fphys-16-1548737-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cc8/12368429/99bc327cb63f/fphys-16-1548737-g002.jpg

相似文献

[1]
Acupuncture as an adjunct therapy for enhancing endometrial receptivity in female infertility: a literature review.

Front Physiol. 2025-8-7

[2]
Unveiling the molecular mechanisms of human platelet lysate in enhancing endometrial receptivity.

Hum Reprod. 2025-7-15

[3]
Podocalyxin is a key negative regulator of human endometrial epithelial receptivity for embryo implantation.

Hum Reprod. 2021-4-20

[4]
Pre-operative endometrial thinning agents before endometrial destruction for heavy menstrual bleeding.

Cochrane Database Syst Rev. 2013-11-15

[5]
Prescription of Controlled Substances: Benefits and Risks

2025-1

[6]
Endometrial injury for pregnancy following sexual intercourse or intrauterine insemination.

Cochrane Database Syst Rev. 2022-10-24

[7]
Endometrial injury for pregnancy following sexual intercourse or intrauterine insemination.

Cochrane Database Syst Rev. 2016-6-14

[8]
Complementary therapies for acne vulgaris.

Cochrane Database Syst Rev. 2015-1-19

[9]
Pre-operative endometrial thinning agents before endometrial destruction for heavy menstrual bleeding.

Cochrane Database Syst Rev. 2002

[10]
Acupuncture as an alternative treatment for polycystic ovary syndrome: Effects on ovulation rate, pregnancy rate and endometrial receptivity.

Complement Ther Med. 2025-7-22

本文引用的文献

[1]
Acupuncture and Bushen Quyu decoction improved endometrial receptivity, hormone secretion, and uterine artery blood flow for repeated implantation failure patients undergoing in vitro fertilization and embryo transfer.

Drug Discov Ther. 2025-1-14

[2]
Effect of electroacupuncture pre-conditioning on the expression rhythm of core clock gene Bmal1 in uterine tissue of controlled hyperstimulation rats.

Zhen Ci Yan Jiu. 2024-7-25

[3]
Acupuncture combined with gonadotropin-releasing hormone agonists improves endometrial receptivity and pregnancy outcome in patients with recurrent implantation failure of in vitro fertilization-embryo transfer.

J Assist Reprod Genet. 2024-8

[4]
Immediate Effect of Electro-acupuncture on Endometrial Blood Flow in Patients with Recurrent Implantation Failure: A Randomized Controlled Trial.

Chin J Integr Med. 2024-4

[5]
Molecular Determinants of Uterine Receptivity: Comparison of Successful Implantation, Recurrent Miscarriage, and Recurrent Implantation Failure.

Int J Mol Sci. 2023-12-18

[6]
Observation of the therapeutic effect of needling combined with herb-separated moxibustion on recurrent implantation failure of kidney deficiency and blood stasis.

Zhongguo Zhen Jiu. 2023-12-12

[7]
The effects of laser acupuncture dosage at PC6 (Neiguan) on brain reactivity: a pilot resting-state fMRI study.

Front Neurosci. 2023-10-12

[8]
[Clinical study on the effect of acupuncture on pregnancy outcome in patients with prethrombotic infertility after repeated implantation failure].

Zhen Ci Yan Jiu. 2023-9-25

[9]
[Electroacupuncture combined with bone marrow mesenchymal stem cell transplantation promotes repair of thin endometrium by regulating SDF-1/CXCR4 signaling].

Zhen Ci Yan Jiu. 2023-9-25

[10]
Using organoids to investigate human endometrial receptivity.

Front Endocrinol (Lausanne). 2023

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索