Zhang Rui, Wong Ngai Sze, Chung Sze Long, Kwan Chi Keung, Kwan Tsz Ho, Lee Shui Shan
Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong, China.
S.H. Ho Research Centre for Infectious Diseases, The Chinese University of Hong Kong, Hong Kong, China.
Hum Vaccin Immunother. 2025 Dec;21(1):2440956. doi: 10.1080/21645515.2024.2440956. Epub 2024 Dec 22.
Human papillomavirus (HPV) vaccination could reduce HPV infection in men who have sex with men (MSM), but the published statistics on HPV vaccination uptake in MSM were scarce globally. This study estimated the uptake and profiled the service preferences of HPV vaccination of Chinese MSM in Hong Kong. Adult MSM were recruited through non-governmental organizations (NGOs) and online channels for completing an online baseline survey. Factors associated with self-reported history of HPV vaccination were identified using multivariable stepwise logistic regression model. Totally 701 Chinese MSM completed the online baseline survey, with the median age of 30 y (interquartile range [IQR] 26-35, range 18-67), and 23% of them had received HPV vaccination. More than half of vaccinated MSM (72%) rated convenient or very convenient for local HPV vaccination services. Among unvaccinated MSM, 50% considered high cost of HPV vaccine as the barrier of vaccination, 67% expressed willingness to pay below USD 128 per vaccine dose, and 65% preferred receiving vaccination in private clinics. MSM who had taken HIV pre-exposure prophylaxis (PrEP) ( < .001), had been tested for HPV ( = .018), and had ( = .005) multiple regular sex partners in the past 6 months were more likely to be vaccinated. The HPV vaccination uptake of Chinese MSM in Hong Kong remains low (23%), and high HPV vaccine cost is the main barrier. Preventive behaviors (HIV PrEP use and HPV testing) and high-risk sexual behavior (multiple regular sex partners) are potential targets for intervention to increase the uptake of HPV vaccination in MSM.
人乳头瘤病毒（HPV）疫苗接种可降低男男性行为者（MSM）的HPV感染率，但全球范围内关于MSM人群HPV疫苗接种率的公开统计数据稀缺。本研究估算了中国香港地区MSM人群的HPV疫苗接种率，并分析了他们对HPV疫苗接种服务的偏好。通过非政府组织（NGO）和网络渠道招募成年MSM人群，完成一项在线基线调查。使用多变量逐步逻辑回归模型确定与自我报告的HPV疫苗接种史相关的因素。共有701名中国香港地区的MSM人群完成了在线基线调查，年龄中位数为30岁（四分位间距[IQR]为26 - 35岁，范围为18 - 67岁），其中23%的人接种过HPV疫苗。超过一半的接种者（72%）认为当地的HPV疫苗接种服务方便或非常方便。在未接种者中，50%认为HPV疫苗成本高是接种的障碍，67%表示愿意每剂疫苗支付低于128美元，65%更倾向于在私人诊所接种。在过去6个月内接受过HIV暴露前预防（PrEP）（<0.001）、接受过HPV检测（=0.018）以及有（=0.005）多个固定性伴侣的MSM人群更有可能接种疫苗。中国香港地区MSM人群的HPV疫苗接种率仍然较低（23%），高疫苗成本是主要障碍。预防行为（使用HIV PrEP和进行HPV检测）和高危性行为（多个固定性伴侣）是提高MSM人群HPV疫苗接种率的潜在干预目标。
