Corcoran M O, Thomas D M, Lim A, Berry R J, Milroy E J
Br J Urol. 1985 Feb;57(1):40-2. doi: 10.1111/j.1464-410x.1985.tb08981.x.
Fifty-three consecutive, unselected patients with invasive bladder cancer, Stage T2 to T3, treated by radical radiotherapy have been reviewed. Cystectomy was reserved for patients with significant worsening of disease during treatment, histologically confirmed persistent or recurrent invasive tumour after treatment, or patients with intolerable symptoms due to radiation cystitis. In 64% of our patients a favourable tumour response to radiotherapy was seen, while a further 31% showed disease progression either during or on completion of radiotherapy. Cystectomy was performed on 22% of patients, mainly for radiation cystitis, and was not associated with a significant operative mortality rate. The crude 5-year survival rate was 42%. We conclude that radical radiotherapy is as effective as other forms of treatment for invasive bladder cancer, but that there remains a need to identify those bladder tumours destined to respond poorly to radiotherapy at an earlier stage.
对53例连续入选的T2至T3期浸润性膀胱癌患者进行了根治性放疗回顾性研究。对于治疗期间疾病显著恶化、治疗后经组织学证实有持续性或复发性浸润性肿瘤，或因放射性膀胱炎出现无法耐受症状的患者，才进行膀胱切除术。在我们的患者中，64%对放疗有良好的肿瘤反应，另有31%在放疗期间或放疗结束时出现疾病进展。22%的患者接受了膀胱切除术，主要原因是放射性膀胱炎，且手术死亡率不高。5年粗生存率为42%。我们得出结论，根治性放疗与浸润性膀胱癌的其他治疗方法效果相当，但仍需要在更早阶段识别出那些对放疗反应不佳的膀胱肿瘤。
