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膝神经的药理阻滞治疗膝关节骨关节炎

Pharmacological Block of Genicular Nerves in the Treatment of Knee Osteoarthritis.

作者信息

Fonseca Bruno Paulo Marques da, Nakama Gilberto Yoshinobu, Marques Guilherme Loterio, Araujo Guilherme Ferrari de, Soares Fernanda Martinho, Canto Alan Motta do

机构信息

Departamento de Ortopedia, Hospital e Maternidade Metropolitano, São Paulo, SP, Brasil.

Departamento de Ortopedia e Cirurgia do Joelho, Instituto Prevent Senior, São Paulo, SP, Brasil.

出版信息

Rev Bras Ortop (Sao Paulo). 2024 Dec 21;59(6):e888-e894. doi: 10.1055/s-0044-1792117. eCollection 2024 Dec.

DOI:10.1055/s-0044-1792117
PMID:39711638
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11663067/
Abstract

To evaluate the clinical and functional outcomes of the pharmacological block of the genicular nerves as a modality in the therapeutic arsenal for knee osteoarthritis, since it is simple, safe, and minimally invasive.  The pharmacological block of the genicular nerves was performed in 20 patients with grades 3 and 4 knee osteoarthritis per the Kellgren-Lawrence classification. We assessed their clinical and functional outcomes one, three, and six months after the procedure.  Of the 20 patients undergoing the procedure, 16 (80%) presented an excellent response in the first month of outpatient follow-up, since their pain level went from 8/9 to 2/3; 2 subjects presented a partial response, and 2 others did not respond to the treatment.  The pharmacological block of the genicular nerves is efficient in reducing pain and improving the performance of daily activities by the patients, especially up to three months after the procedure.

摘要

为评估膝神经药物阻滞作为膝骨关节炎治疗手段的临床和功能结局,因其操作简单、安全且微创。

根据凯尔格伦-劳伦斯分类法,对20例3级和4级膝骨关节炎患者进行了膝神经药物阻滞。我们在术后1个月、3个月和6个月评估了他们的临床和功能结局。

在接受该手术的20例患者中,16例(80%)在门诊随访的第一个月表现出极佳的反应,因为他们的疼痛程度从8/9降至2/3;2例患者有部分反应,另外2例对治疗无反应。

膝神经药物阻滞在减轻疼痛和改善患者日常活动能力方面是有效的,尤其是在术后三个月内。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ece/11663067/607b64496bb7/10-1055-s-0044-1792117-i2300055pt-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ece/11663067/cde2da225497/10-1055-s-0044-1792117-i2300055en-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ece/11663067/3a23f75c3f06/10-1055-s-0044-1792117-i2300055en-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ece/11663067/10b70da9f216/10-1055-s-0044-1792117-i2300055en-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ece/11663067/d5bc272a055f/10-1055-s-0044-1792117-i2300055en-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ece/11663067/7f609bd12461/10-1055-s-0044-1792117-i2300055pt-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ece/11663067/a2b6eac8dd42/10-1055-s-0044-1792117-i2300055pt-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ece/11663067/6d2e2b68fbe7/10-1055-s-0044-1792117-i2300055pt-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ece/11663067/607b64496bb7/10-1055-s-0044-1792117-i2300055pt-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ece/11663067/cde2da225497/10-1055-s-0044-1792117-i2300055en-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ece/11663067/3a23f75c3f06/10-1055-s-0044-1792117-i2300055en-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ece/11663067/10b70da9f216/10-1055-s-0044-1792117-i2300055en-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ece/11663067/d5bc272a055f/10-1055-s-0044-1792117-i2300055en-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ece/11663067/7f609bd12461/10-1055-s-0044-1792117-i2300055pt-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ece/11663067/a2b6eac8dd42/10-1055-s-0044-1792117-i2300055pt-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ece/11663067/6d2e2b68fbe7/10-1055-s-0044-1792117-i2300055pt-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ece/11663067/607b64496bb7/10-1055-s-0044-1792117-i2300055pt-4.jpg

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本文引用的文献

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Korean J Pain. 2023 Oct 1;36(4):450-457. doi: 10.3344/kjp.23200. Epub 2023 Sep 21.
2
Effects of recurrent intra-articular corticosteroid injections for osteoarthritis at 3 months and beyond: a systematic review and meta-analysis in comparison to other injectables.3 个月及以上反复关节内注射皮质类固醇治疗骨关节炎的效果:与其他注射剂相比的系统评价和荟萃分析。
Osteoarthritis Cartilage. 2022 Dec;30(12):1658-1669. doi: 10.1016/j.joca.2022.07.011. Epub 2022 Sep 13.
3
Ultrasound-guided Genicular Nerve Blockade With Pharmacological Agents for Chronic Knee Osteoarthritis: A Systematic Review.
超声引导下药物关节内神经阻滞治疗慢性膝骨关节炎的系统评价。
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4
Procedural Treatments for Knee Osteoarthritis: A Review of Current Injectable Therapies.膝关节骨关节炎的程序性治疗:当前可注射疗法综述
Pain Res Manag. 2020 Feb 18;2020:3873098. doi: 10.1155/2020/3873098. eCollection 2020.
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Non-operative treatment options for knee osteoarthritis.膝关节骨关节炎的非手术治疗选择
Ann Transl Med. 2019 Oct;7(Suppl 7):S245. doi: 10.21037/atm.2019.06.68.
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