Lakshmanan Suvasini, Gimelli Alessia
University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
Fondazione Toscana Gabriele Monasterio, Department of Imaging, Pisa, Italy.
Int J Cardiol Congenit Heart Dis. 2023 Jan 20;12:100441. doi: 10.1016/j.ijcchd.2023.100441. eCollection 2023 Jun.
Advances in diagnostics and interventional/surgical treatment of patients with congenital heart disease (CHD) over the past several decades, allows a decline in rates of all-cause mortality, with a significant reduction in proportion of infant and childhood deaths with severe forms of CHD. However, the risk of premature death in adults with complex CHD remains elevated. A growing body of evidence has recently described the impact of non-cardiovascular comorbidities such as cancers, on morbidity, health care utilizations and mortality in adult patients with CHD. Aim of this review is to provide an appraisal of the current evidence that report associations between CHD and increased cancer risk in children and adults, and provide an overview of the specific risk factors.
在过去几十年中，先天性心脏病（CHD）患者的诊断以及介入/手术治疗取得了进展，这使得全因死亡率有所下降，患有严重形式CHD的婴儿和儿童死亡比例显著降低。然而，患有复杂CHD的成人过早死亡的风险仍然很高。最近，越来越多的证据描述了诸如癌症等非心血管合并症对患有CHD的成年患者的发病率、医疗保健利用率和死亡率的影响。本综述的目的是评估当前关于CHD与儿童和成人癌症风险增加之间关联的证据，并概述具体的风险因素。
