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危重症患者血清甲状腺激素与白细胞介素-1β水平及死后组织脱碘酶活性之间的关系

Relationship between serum thyroid hormone and interleukin-1b levels and postmortem tissue deiodinase activity in critically ill patients.

作者信息

Zhong Zhenzhou, Xiao Xiaoliu

机构信息

Ganzhou People's Hospital, Department of Emergency, Ganzhou City, JiangXi Province, China.

出版信息

J Med Biochem. 2024 Sep 6;43(5):681-689. doi: 10.5937/jomb0-46999.

Abstract

BACKGROUND

This study investigated the relationship between serum thyroid hormones and interleukin-1b (IL-1β) levels and postmortem tissue deiodinase activity in critically ill patients.

METHODS

Serum thyroid hormones and IL-1β were measured on the 5th, 15th, and last day of 80 critically ill patients. Forty of these patients were non-survived, and liver and skeletal muscle were harvested to analyze type 1, 2, and 3 iodothyronine deiodinases (D1, D2, and D3) activity.

摘要

背景

本研究调查了重症患者血清甲状腺激素与白细胞介素-1β(IL-1β)水平以及死后组织脱碘酶活性之间的关系。

方法

对80例重症患者在第5天、第15天和最后一天测定血清甲状腺激素和IL-1β。其中40例患者死亡,采集肝脏和骨骼肌分析1型、2型和3型碘甲状腺原氨酸脱碘酶(D1、D2和D3)活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c43c/11662955/0f97b78cc0de/jomb-43-5-2405681Z_g001.jpg

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