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类风湿性关节炎与心力衰竭:一篇叙述性综述

Rheumatoid Arthritis and Heart Failure: A Narrative Review.

作者信息

Deepika Korimerla, Moraboina Sai Lokesh, Vineetha Bodipudi, Kodali Chandana Sai, Guddeti Hema Sreelakshmi, Poladi Sanjana, Digumurthy Chandana Priya, Mellamputi Jashika

机构信息

Internal Medicine, Apollo Institute of Medical Sciences and Research, Chittoor, IND.

Respiratory Medicine, University of Chester, Chester, GBR.

出版信息

Cureus. 2024 Nov 22;16(11):e74238. doi: 10.7759/cureus.74238. eCollection 2024 Nov.

DOI:10.7759/cureus.74238
PMID:39712804
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11663431/
Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory process involving the joints and the cartilage. Early diagnosis and treatment of RA are crucial to prevent further complications like heart failure (HF), cervical subluxation, membranous glomerulonephritis, and parenchymal lung disease. HF is the leading cause of death in various chronic illnesses. The pathophysiology of HF varies based on the type of illness. In this review, our main objective was to look into the association between RA and HF by examining the pathogenesis, risk factors, and treatment of HF in RA. We also discuss the role of the inflammatory markers associated with HF in the pathogenesis. The treatment of anti-inflammatory drugs in HF associated with RA is also discussed. We also address the risk factors associated with RA so that the development of complications like HF can be reduced in this patient population.

摘要

类风湿性关节炎(RA)是一种涉及关节和软骨的慢性炎症过程。RA的早期诊断和治疗对于预防诸如心力衰竭(HF)、颈椎半脱位、膜性肾小球肾炎和实质性肺病等进一步并发症至关重要。HF是各种慢性疾病中的主要死亡原因。HF的病理生理学因疾病类型而异。在本综述中,我们的主要目的是通过研究RA中HF的发病机制、危险因素和治疗方法来探讨RA与HF之间的关联。我们还讨论了与HF相关的炎症标志物在发病机制中的作用。还讨论了与RA相关的HF中抗炎药物的治疗。我们还阐述了与RA相关的危险因素,以便在该患者群体中减少诸如HF等并发症的发生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad18/11663431/26488f873385/cureus-0016-00000074238-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad18/11663431/26488f873385/cureus-0016-00000074238-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad18/11663431/26488f873385/cureus-0016-00000074238-i01.jpg

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本文引用的文献

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Front Immunol. 2024 May 28;15:1377432. doi: 10.3389/fimmu.2024.1377432. eCollection 2024.
2
Risk of extended major adverse cardiovascular event endpoints with tofacitinib versus TNF inhibitors in patients with rheumatoid arthritis: a post hoc analysis of a phase 3b/4 randomised safety study.托法替布对比 TNF 抑制剂治疗类风湿关节炎患者的延长主要不良心血管事件终点的风险:一项 3b/4 期随机安全性研究的事后分析。
RMD Open. 2024 Apr 12;10(2):e003912. doi: 10.1136/rmdopen-2023-003912.
3
Cardiovascular complications of rheumatoid arthritis.类风湿关节炎的心血管并发症。
Curr Opin Rheumatol. 2024 May 1;36(3):209-216. doi: 10.1097/BOR.0000000000001004. Epub 2024 Feb 9.
4
Associations between rheumatoid arthritis, incident heart failure, and left ventricular ejection fraction.类风湿关节炎与心力衰竭事件及左心室射血分数的相关性。
Am Heart J. 2023 May;259:42-51. doi: 10.1016/j.ahj.2023.02.001. Epub 2023 Feb 10.
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Prospective changes in diastolic function in patients with rheumatoid arthritis.类风湿关节炎患者舒张功能的前瞻性变化。
Arthritis Res Ther. 2022 Aug 5;24(1):184. doi: 10.1186/s13075-022-02864-0.
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