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本文引用的文献

1
Aryl hydrocarbon receptor dynamics in esophageal squamous cell carcinoma: From immune modulation to therapeutic opportunities.食管鳞状细胞癌中的芳烃受体动力学:从免疫调节到治疗机遇
World J Exp Med. 2024 Sep 20;14(3):96269. doi: 10.5493/wjem.v14.i3.96269.
2
USP21-mediated G3BP1 stabilization accelerates proliferation and metastasis of esophageal squamous cell carcinoma via activating Wnt/β-Catenin signaling.USP21介导的G3BP1稳定通过激活Wnt/β-连环蛋白信号通路加速食管鳞状细胞癌的增殖和转移。
Oncogenesis. 2024 Jun 21;13(1):23. doi: 10.1038/s41389-024-00524-3.
3
METTL3-mediated upregulation of FAM135B promotes EMT of esophageal squamous cell carcinoma via regulating the Wnt/β-catenin pathway.METTL3 通过调控 Wnt/β-catenin 通路促进食管鳞癌细胞 EMT。
Am J Physiol Cell Physiol. 2024 Aug 1;327(2):C329-C340. doi: 10.1152/ajpcell.00529.2023. Epub 2024 Jun 17.
4
Final analysis of camrelizumab plus chemotherapy for untreated advanced or metastatic esophageal squamous cell carcinoma: The ESCORT-1st trial.卡瑞利珠单抗联合化疗治疗未经治疗的晚期或转移性食管鳞癌的最终分析:ESCORT-1st 试验。
Med. 2024 Sep 13;5(9):1137-1149.e3. doi: 10.1016/j.medj.2024.05.008. Epub 2024 Jun 12.
5
The modern human aryl hydrocarbon receptor is more active when ancestralized by genome editing.经基因组编辑后,现代人类芳香烃受体的活性更高。
Proc Natl Acad Sci U S A. 2024 May 28;121(22):e2402159121. doi: 10.1073/pnas.2402159121. Epub 2024 May 13.
6
Metabolic landscape of head and neck squamous cell carcinoma informs a novel kynurenine/Siglec-15 axis in immune escape.头颈部鳞状细胞癌的代谢全景揭示了免疫逃逸中的新型犬尿氨酸/Siglec-15 轴。
Cancer Commun (Lond). 2024 Jun;44(6):670-694. doi: 10.1002/cac2.12545. Epub 2024 May 12.
7
The components of the AhR-molecular chaperone complex differ depending on whether the ligands are toxic or non-toxic.芳香烃受体-分子伴侣复合物的组成取决于配体是有毒的还是无毒的。
FEBS Lett. 2024 Jun;598(12):1478-1490. doi: 10.1002/1873-3468.14871. Epub 2024 Apr 11.
8
Mechanisms underlying aryl hydrocarbon receptor-driven divergent macrophage function.芳基烃受体驱动的巨噬细胞功能分歧的机制。
Toxicol Sci. 2024 Jun 26;200(1):1-10. doi: 10.1093/toxsci/kfae050.
9
Oral tryptophan activates duodenal aryl hydrocarbon receptor in healthy subjects: a crossover randomized controlled trial.口服色氨酸激活健康受试者十二指肠芳烃受体:一项交叉随机对照试验。
Am J Physiol Gastrointest Liver Physiol. 2024 Jun 1;326(6):G687-G696. doi: 10.1152/ajpgi.00306.2023. Epub 2024 Apr 9.
10
Aryl hydrocarbon receptor as a drug target in advanced prostate cancer therapy - obstacles and perspectives.芳烃受体作为晚期前列腺癌治疗中的药物靶点——障碍与前景
Transcription. 2025 Feb;16(1):47-66. doi: 10.1080/21541264.2024.2334106. Epub 2024 Mar 28.

利用芳烃受体动力学:揭示食管鳞状细胞癌的治疗途径。

Harnessing aryl hydrocarbon receptor dynamics: Unveiling therapeutic pathways in esophageal squamous cell carcinoma.

作者信息

Cheng Chun-Han, Hao Wen-Rui, Cheng Tzu-Hurng

机构信息

Department of Medical Education, Linkou Chang Gung Memorial Hospital, Taoyuan City 33305, Taiwan.

Division of Cardiology, Shuang Ho Hospital, Ministry of Health and Welfare, Taipei Medical University, New Taipei City 23561, Taiwan.

出版信息

World J Exp Med. 2024 Dec 20;14(4):98599. doi: 10.5493/wjem.v14.i4.98599.

DOI:10.5493/wjem.v14.i4.98599
PMID:39713081
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11551697/
Abstract

This editorial discusses the insightful minireview by Rahmati . The minireview delves into the role of the aryl hydrocarbon receptor in the development and progression of esophageal squamous cell carcinoma, highlighting its potential as a promising therapeutic target. The authors concisely summarize the current understanding of how aryl hydrocarbon receptor modulation influences immune responses and the tumor microenvironment, offering fresh perspectives on therapeutic strategies. This editorial aimed to emphasize the significance of these findings and their potential impact on future research and clinical practices for the management of esophageal squamous cell carcinoma.

摘要

这篇社论讨论了拉赫马蒂颇具见地的小综述。该小综述深入探讨了芳烃受体在食管鳞状细胞癌发生发展中的作用,强调了其作为一个有前景的治疗靶点的潜力。作者简要总结了目前对芳烃受体调节如何影响免疫反应和肿瘤微环境的理解,为治疗策略提供了新的视角。这篇社论旨在强调这些发现的重要性及其对食管鳞状细胞癌管理的未来研究和临床实践的潜在影响。