Wang Xilong, Liu Ziqi, Zhou Zhenyu, Zhang Junze, Wang Yanru, He Shihao, Wang Rong
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Department of Pathology, Stanford University School of Medicine, Stanford, CA, United States.
Front Hum Neurosci. 2024 Dec 6;18:1502318. doi: 10.3389/fnhum.2024.1502318. eCollection 2024.
Cognitive dysfunction is common in Moyamoya disease (MMD). However, current knowledge of cognitive impairment in MMD is inadequate. In this review, we explored the characteristics of altered cognitive function associated with MMD and offered recommendations aimed at guiding potential research endeavors into the cognitive dysfunction in MMD. Cognitive functions, including executive function, intelligence, memory and so on, show characteristic declines in MMD. The effects of cerebral revascularization surgery on cognitive impairment are controversial. Currently, there is still a lack of relevant research on cognitive impairment. Research on the pathogenesis and etiology associated with Moyamoya disease as well as long-term cohort studies, are important future directions.
认知功能障碍在烟雾病（MMD）中很常见。然而，目前对MMD认知损害的了解并不充分。在本综述中，我们探讨了与MMD相关的认知功能改变的特征，并提出了旨在指导MMD认知功能障碍潜在研究工作的建议。认知功能，包括执行功能、智力、记忆等，在MMD中呈现出特征性下降。脑血运重建手术对认知损害的影响存在争议。目前，关于认知损害仍缺乏相关研究。对烟雾病相关发病机制和病因的研究以及长期队列研究，是未来重要的研究方向。
