Maeda K, VanSlyck E J, VanDyke D L
Cancer Genet Cytogenet. 1985 Mar 1;16(1):81-9. doi: 10.1016/0165-4608(85)90080-9.
A 71-year-old woman with multiple myeloma was successfully managed for 8 years with melphalan (total dose 2056 mg). She developed a refractory anemia (myelodysplastic state), which terminated in acute eosinophilic leukemia. This form of acute leukemia, induced by chemotherapy, appears to be very rare. The cytogenetic changes, including 5q- and monosomy 7, were similar to those observed in other patients with acute nonlymphocytic leukemia as a secondary malignancy following treatments of other primary tumors.
一名71岁的多发性骨髓瘤女性患者接受美法仑治疗（总剂量2056毫克），成功治疗了8年。她发展为难治性贫血（骨髓增生异常状态），最终演变为急性嗜酸性粒细胞白血病。这种由化疗诱导的急性白血病形式似乎非常罕见。细胞遗传学改变，包括5号染色体长臂缺失（5q-）和7号染色体单体，与其他原发性肿瘤治疗后继发恶性肿瘤的急性非淋巴细胞白血病患者中观察到的改变相似。
