Minamisawa Genki, Dong Mingyuan, O'Connor Daniel H
Solomon H. Snyder Department of Neuroscience, Kavli Neuroscience Discovery Institute, Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD.
Zanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD.
bioRxiv. 2024 Dec 12:2024.12.06.627272. doi: 10.1101/2024.12.06.627272.
Somatosensory cortex activity relates both to sensation and movement, reflecting their intimate relationship, but the extent and nature of sensory-motor interactions in the somatosensory cortex remain unclear. Here, we investigated perception-related sensory and motor signals in the whisker areas of mouse primary (wS1) and secondary (wS2) somatosensory cortices. We recorded neuronal activity while mice performed a whisker detection task using two alternative lickports, one each to indicate the presence or absence of a whisker deflection on a given trial. One group of mice reported the presence of the whisker stimulus by licking at the port on the same ("congruent") side of the animal as the stimulated whisker, whereas a second group of mice did so by licking at the opposite ("incongruent") side. Activity of single neurons in wS1 and wS2 correlated with perceptual choice. This choice-related activity was enhanced when responding to the congruent side. wS2 neurons projecting along two output pathways-to wS1 or to whisker secondary motor cortex, wM2-also showed choice-related activity, but differed in their dependence on congruence and in the effects of optogenetic manipulation. Thus, somatosensory cortex contains pathway- and action-specific choice-related activity.
体感皮层活动与感觉和运动均相关，反映了它们之间的紧密关系，但体感皮层中感觉运动相互作用的程度和性质仍不清楚。在这里，我们研究了小鼠初级（wS1）和次级（wS2）体感皮层的触须区域中与感知相关的感觉和运动信号。我们记录了神经元活动，同时小鼠使用两个交替的舔舐端口执行触须检测任务，每个端口用于在给定试验中指示触须是否发生偏转。一组小鼠通过舔舐动物与受刺激触须同侧（“一致”）的端口来报告触须刺激的存在，而另一组小鼠则通过舔舐相对侧（“不一致”）的端口来报告。wS1和wS2中单个神经元的活动与感知选择相关。当对一致侧做出反应时，这种与选择相关的活动会增强。沿两条输出通路投射的wS2神经元——一条投射到wS1，另一条投射到触须次级运动皮层wM2——也表现出与选择相关的活动，但在对一致性的依赖以及光遗传学操纵的影响方面存在差异。因此，体感皮层包含与通路和动作特异性相关的选择活动。
