Cheng Tian, Diarbakerli Elias, Simony Ane, Østerheden Andersen Mikkel, Danielsson Aina, Kere Juha, Einarsdottir Elisabet, Gerdhem Paul
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Department of Orthopedics and Hand Surgery, Uppsala University Hospital, Uppsala, Sweden.
Pain Rep. 2024 Dec 19;10(1):e1227. doi: 10.1097/PR9.0000000000001227. eCollection 2025 Feb.
Back pain is common in idiopathic scoliosis. The aim of this study was to study known genetic variants associated with pain in individuals with idiopathic scoliosis.
We included 1442 individuals with juvenile or adolescent idiopathic scoliosis from Sweden and Denmark. Single nucleotide variants (SNV) genotyping was performed on 37 SNVs. Pain was assessed using 2 questionnaires. The mean pain domain score on the Scoliosis Research Society 22 revised questionnaire (SRS-22r) ranging between 1 (worst) and 5 (best) was dichotomized into a "back pain group" (score <4) and a "no back pain group" (score ≥4). The EuroQol 5-dimensions (EQ-5D) 3 level pain domain was dichotomized into a "no pain group" and a "pain group." Odds ratios were used to describe the associations.
Based on the SRS-22r pain domain scores, 456 individuals (32%) reported back pain. Based on the EQ-5D questionnaire, 813 individuals (56%) reported moderate or extreme pain/discomfort. The odds ratio for the associations between the selected genetic variants and back pain or pain in general as measured with SRS-22r and EQ-5D-3L ranged between 0.88 to 1.17 and 0.86 to 1.16, with -values ranging between 0.08 to 0.99 and 0.08 to 0.95.
This study suggests that known genetic variants associated with pain do not play a significant role in the development of pain in individuals with idiopathic scoliosis.
背痛在特发性脊柱侧凸中很常见。本研究的目的是研究与特发性脊柱侧凸患者疼痛相关的已知基因变异。
我们纳入了来自瑞典和丹麦的1442例青少年或青春期特发性脊柱侧凸患者。对37个单核苷酸变异（SNV）进行基因分型。使用2份问卷评估疼痛情况。脊柱侧凸研究学会22项修订问卷（SRS - 22r）上的平均疼痛领域评分范围为1（最差）至5（最佳），被分为“背痛组”（评分<4）和“无背痛组”（评分≥4）。欧洲五维健康量表（EQ - 5D）的3级疼痛领域被分为“无疼痛组”和“疼痛组”。使用优势比来描述相关性。
根据SRS - 22r疼痛领域评分，456例患者（32%）报告有背痛。根据EQ - 5D问卷，813例患者（56%）报告有中度或重度疼痛/不适。所选基因变异与用SRS - 22r和EQ - 5D - 3L测量的背痛或总体疼痛之间的关联优势比在0.88至1.17和0.86至1.16之间，P值在0.08至0.99和0.08至0.95之间。
本研究表明，与疼痛相关的已知基因变异在特发性脊柱侧凸患者疼痛的发生中不发挥重要作用。
