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应对抗菌素耐药性的进展。

Advances in addressing antimicrobial resistance.

作者信息

Carson C A, Weese J S

出版信息

Rev Sci Tech. 2024 Dec;Special Edition:113-123. doi: 10.20506/rst.SE.3565.

Abstract

Antimicrobial resistance (AMR) has been described as a silent pandemic - one that is ever-present, ubiquitous and growing but often insidious and overlooked. A true One Health issue, AMR affects people, animals, plants, crops and the environment in complex and interconnected but poorly understood ways, and the impact will continue to increase. In animals, AMR affects animal health, welfare and production and is also considered a food safety, food security and substantial economic issue. This article describes recent advances in addressing AMR in bacteria from animals, focusing on surveillance, applied stewardship, new drug development and alternatives to antimicrobials, strengthening animal health systems, changes in global awareness, and obstacles to effective surveillance and stewardship.

摘要

抗菌药物耐药性(AMR)被描述为一场无声的大流行——一种一直存在、无处不在且不断蔓延,但往往隐匿且被忽视的大流行。作为一个真正的“同一健康”问题,抗菌药物耐药性以复杂、相互关联但却鲜为人知的方式影响着人类、动物、植物、农作物和环境,而且其影响还将持续加剧。在动物领域,抗菌药物耐药性影响动物健康、福利和生产,同时也被视为食品安全、粮食安全和重大经济问题。本文介绍了在应对动物源细菌抗菌药物耐药性方面的最新进展,重点关注监测、应用管理、新药研发以及抗菌药物替代品、加强动物卫生系统、全球意识的变化,以及有效监测和管理的障碍。

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